Document Detail


Barbiturate alteration of respiratory rhythm and drive in isolated brainstem-spinal cord of newborn rat: studies at normal and hyperbaric pressure.
MedLine Citation:
PMID:  1997065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High pressure and anaesthetic agents are mutual antagonists in intact animals, but antagonism is not observed in isolated nerve cells. In order to test the hypothesis that a neural network might display pressure-anaesthetic antagonism not found in simpler systems, we have examined the effects of pentobarbitone at normal pressure and at 10.1 MPa helium pressure on the rhythmic activity of medullary respiratory centres of isolated brainstem and spinal cord from 0-3 day old rats. Pentobarbitone 5-80 mumol litre-1 depressed the frequency, amplitude and area of spontaneous bursts recorded from C5, reduced respiratory drive, and altered the response to trigeminal nerve root stimulation. Compression to 10.1 MPa decreased ventilatory frequency and respiratory drive, and either did not interact with or enhanced the depressant effects of pentobarbitone. Pentobarbitone and helium pressure altered the response to trigeminal nerve root stimulation in the same manner. The results are consistent with additive rather than antagonistic effects of pressure and a barbiturate on the determinants of output from the respiratory centre-motor neurone pathway. Pressure-anaesthetic antagonism may be a property unique to the neural circuitry which underlies awake behaviour and pressure-induced seizures, rather than reflecting a fundamental molecular-level antagonism.
Authors:
A Tarasiuk; Y Grossman; J J Kendig
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  66     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-04-02     Completed Date:  1991-04-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  88-96     Citation Subset:  IM    
Affiliation:
Unit of Physiology, Faculty for Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects
Animals
Animals, Newborn / physiology
Atmospheric Pressure
Brain Stem / drug effects*
Depression, Chemical
Motor Neurons / physiology
Phenobarbital / pharmacology*
Rats
Respiratory Center / drug effects
Spinal Cord / drug effects*
Time Factors
Trigeminal Nerve / physiology
Grant Support
ID/Acronym/Agency:
NS13108/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
50-06-6/Phenobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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