Document Detail


Banding studies of chromosomal abnormalities in patients with acute lymphocytic leukemia.
MedLine Citation:
PMID:  367578     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Karyotypes were analyzed by routine Giemsa and quinacrine fluorescence for 16 patients with acute lymphocytic leukemia [ten adults (18 to 51 years) and six children (3 to 15 years)]. Four patients had received previous therapy, but all 16 had active disease when they were first studied. Eight patients (five untreated) had a normal karyotype initially; however, three of these developed a chromosomal abnormality during relapse. Eight patients had a chromosomal abnormality in their initial samples. Each of the 11 patients had different abnormalities. All chromosomes except Nos. 3, 5, 15, 16, and Y were involved in the various aneuploidies. One patient had a Ph1 chromosome due to a translocation with No. 21: t(21;22)(q22;q11). A patient with B-cell acute lymphocytic leukemia had a 14q+ marker in addition to other abnormalities. The median survival of patients with initially normal karyotypes may be longer than that of patients whose karyotypes are abnormal initially.
Authors:
M C Cimino; J D Rowley; A Kinnealey; D Variakojis; H M Golomb
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Publication Detail:
Type:  Case Reports; Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  39     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-04-25     Completed Date:  1979-04-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  227-38     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Antineoplastic Agents / therapeutic use
Child
Child, Preschool
Chromosome Aberrations*
Chromosomes, Human, 21-22 and Y
Clinical Trials as Topic
Female
Humans
Leukemia / genetics
Leukemia, Lymphoid / drug therapy,  genetics*
Male
Middle Aged
Recurrence
Remission, Spontaneous
Time Factors
Chemical
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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