Document Detail


Banana juice reduces bioavailability of levodopa preparation.
MedLine Citation:
PMID:  16327247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study aimed to examine the effects of banana juice on levodopa bioavailability in rats. When a levodopa preparation (EC-Doparl tablets) was orally administered with banana juice made by mixing with a fresh banana and water, there were significant decreases in C(max) (17.4+/-2.5 vs. 8.6+/-3.1 microg/ml; alpha=0.05) and AUC (1882.8+/-49.2 vs. 933.5+/-286.6 microg.min/ml; alpha=0.05) for levodopa. On the other hand, administration of the levodopa preparation with a commercial beverage containing 10% banana juice resulted in no significant change in C(max) or AUC. These results indicate that concomitant intake of levodopa preparations with banana juice, but not with a commercial banana beverage, may cause a drug-food interaction reducing levodopa bioavailability, and we should pay attention to such interactions during levodopa therapy for patients with Parkinson's disease.
Authors:
Yuki Ogo; Nobuyoshi Sunagane; Takafumi Ohta; Tsutomu Uruno
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan     Volume:  125     ISSN:  0031-6903     ISO Abbreviation:  Yakugaku Zasshi     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-01-24     Revised Date:  2006-04-12    
Medline Journal Info:
Nlm Unique ID:  0413613     Medline TA:  Yakugaku Zasshi     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1009-11     Citation Subset:  IM    
Affiliation:
Faculty of Pharmaceutical Sciences, Tokyo University of Science (RIKADAI), 2641 Yamazaki, Noda City 278-8510, Japan.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Antiparkinson Agents / administration & dosage,  pharmacokinetics*
Biological Availability
Food-Drug Interactions*
Levodopa / administration & dosage,  pharmacokinetics*
Male
Musa*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Antiparkinson Agents; 0/Levodopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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