Document Detail

Bambusae caulis in Liquamen Suppresses the Expression of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine in Human Keratinocytes due to Antioxidant Effect.
MedLine Citation:
PMID:  21785648     Owner:  NLM     Status:  In-Data-Review    
Bambusae caulis in Liquamen (BCL), traditional herbal medicine used in East Asia, is known to have antioxidative and immune-regulating properties. We hypothesized that the potential antioxidant effects of BCL might suppress the production of thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in human keratinocytes (HaCaT cell). The immune-regulating effect of BCL was demonstrated by antioxidant capacity using DPPH analysis and DCFH-DA analysis. We found that BCL had strong ROS scavenge effect in HaCaT cell. BCL also showed suppression of IFN-γ-induced expression of TARC and MDC, activation of NF-κB, and, moreover, significant block of IFN-γ-induced degradation and phosphorylation of IκB. However, it had no effects on phosphorylation of p38 MAPK. Collectively, these results suggest that BCL may have a therapeutic potential on skin disease such as atopic dermatitis by inhibiting Th2 chemokines which is due, at least in part, to its antioxidant capacities.
Xu-Feng Qi; Dong-Heui Kim; Yang-Suk Yoon; Soon-Bong Song; Yung-Chien Teng; Dong-Qing Cai; Kyu-Jae Lee
Related Documents :
21864618 - Induction and comparison of siv immunity in ad5 naïve and ad5 immune non-human primates...
22110778 - From the bench to the clinic: new aspects on immunoregulation by vitamin d analogs.
22158548 - Regulatory t cells: banned cells for decades.
21878338 - Cryopreservation of monocytes or differentiated immature dcs leads to an altered cytoki...
23304058 - Macrophage-mediated inflammation and disease: a focus on the lung.
23313858 - Sirt1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine pr...
Publication Detail:
Type:  Journal Article     Date:  2011-07-06
Journal Detail:
Title:  Evidence-based complementary and alternative medicine : eCAM     Volume:  2012     ISSN:  1741-4288     ISO Abbreviation:  Evid Based Complement Alternat Med     Publication Date:  2012  
Date Detail:
Created Date:  2011-07-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101215021     Medline TA:  Evid Based Complement Alternat Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  617494     Citation Subset:  -    
Key Laboratory for Regenerative Medicine, Ministry of Education, Jinan University, Guangzhou 510632, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cinnamomi ramulus Ethanol Extract Exerts Vasorelaxation through Inhibition of Ca Influx and Ca Relea...
Next Document:  Inhibitory effects of glycyrrhetinic Acid on DNA polymerase and inflammatory activities.