Document Detail


Balloon valvuloplasty in the treatment of congenital aortic valve stenosis - A retrospective multicenter survey of more than 1000 patients.
MedLine Citation:
PMID:  20153064     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: The value of balloon valvuloplasty of the aortic valve in childhood is still under debate.
OBJECTIVE: To evaluate the results of the procedure in a retrospective multicenter survey of a large cohort over a long time interval.
METHODS: Retrospective analysis of 1004 patients with balloon valvuloplasty of the aortic valve performed between 9/1985 and 10/2006 at 20 centers in Germany, Austria and Switzerland. Amongst others, the following parameters were evaluated before and after the procedure as well as at the end of follow-up or before surgery: clinical status, left ventricular function, transaortic pressure gradient, degree of aortic regurgitation, freedom from re-intervention or surgery.
PATIENTS: Patients from 1day to 18years of age with aortic valve stenosis were divided into four groups: 334 newborns (1-28days); 249 infants (29-365days); 211 children (1-10years), and 210 adolescents (10-18years).
RESULTS: Median follow-up was 32months (0days to 17.5years). After dilatation the pressure gradient decreased from 65 (±24)mm Hg to 26 (±16)mm Hg and remained stable during follow-up. The newborns were the most affected patients. Approximately 60% of them had clinical symptoms and impaired left ventricular function before intervention. Complication rate was 15% in newborns, 11% in infants and 6% in older children. Independently of age, 50% of all patients were free from surgery 10years after intervention.
CONCLUSIONS: In this retrospective multicenter study, balloon valvuloplasty of the aortic valve has effectively postponed the need for surgery in infants, children and adolescents up to 18years of age.
Authors:
P Ewert; H Bertram; J Breuer; I Dähnert; S Dittrich; A Eicken; M Emmel; G Fischer; R Gitter; M Gorenflo; N Haas; E Kitzmüller; A Koch; O Kretschmar; A Lindinger; I Michel-Behnke; J H Nuernberg; M Peuster; K Walter; P Zartner; F Uhlemann
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Publication Detail:
Type:  Journal Article     Date:  2010-02-11
Journal Detail:
Title:  International journal of cardiology     Volume:  149     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  182-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Deutsches Herzzentrum Berlin, Germany.
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