Document Detail

Balloon-expandable stent treatment of experimental coarctation of the aorta: early hemodynamic and pathological evaluation.
MedLine Citation:
PMID:  10150998     Owner:  NLM     Status:  MEDLINE    
The present study was intended to evaluate the acute and short-term hemodynamic, angiographic, and pathological response to balloon-expandable stent treatment of experimental coarctation of the aorta. A discrete thoracic coarctation was surgically created in six mongrel dogs (two adults, four puppies). Two months postoperatively all six dogs (8.9-30 kg) underwent left heart catheterization and coarctation stenting performed through a femoral artery cutdown. A Palmaz PS-30 stent was advanced to the coarctation through a 10 French sheath, and expanded with an angioplasty balloon chosen to equal the diameter of the proximal aorta (9-12 mm). Stent implantation was successful in each dog. The systolic pressure gradient decreased from 26.3 +/- 9.1 mmHg (mean +/- SE) to 0.5 +/- 0.5 mmHg (P = 0.04), and the coarctation diameter improved from 50 +/- 6% to 82 +/- 6% of the diameter of the proximal descending aorta (P less than 0.01). Follow-up catheterization 4-7 weeks after stenting documented no stent migration, early restenosis, thrombosis, obstruction of arterial side branches, or aneurysm formation. Pathological evaluation of the explanted segments of stented aorta documented that by 6-7 weeks the stents are covered by a neointima composed of intimal proliferation and fibrosis with an endothelial cell surface. These data suggest that balloon-expandable stainless steel stents provide excellent acute and short-term relief of coarctation in this experimental model. Larger and longer-term studies are needed to better assess the incidence of restenosis or aneurysm formation following stenting of coarctation of the aorta.
R H Beekman; D W Muller; P I Reynolds; C Moorehead; K Heidelberger; F M Lupinetti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of interventional cardiology     Volume:  6     ISSN:  0896-4327     ISO Abbreviation:  J Interv Cardiol     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-08-26     Completed Date:  1993-08-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8907826     Medline TA:  J Interv Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  113-23     Citation Subset:  T    
Division of Pediatric Cardiology, Department of Pediatrics, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor.
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MeSH Terms
Aortic Aneurysm
Aortic Coarctation / pathology,  radiography,  surgery*
Evaluation Studies as Topic
Heart Catheterization / methods
Stainless Steel
Reg. No./Substance:
12597-68-1/Stainless Steel

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