Document Detail

Balloon-based in vitro MDI aerosol deposition experiments on the effects of mouthpiece diameter.
MedLine Citation:
PMID:  17497529     Owner:  NLM     Status:  MEDLINE    
For this article, we studied the effects of mouthpiece diameter and flow rate on aerosol penetration efficiency for metered-dose inhaler (MDI) applications. Measurements show that increasing the mouthpiece diameter has a moderate and positive influence on the particle penetration efficiency of the MDI. The particle penetration efficiency increases monotonically with the increase of the mouthpiece diameter from 16 mm to 20 mm. Second, the experiments show that airflow rate has an apparent and significant effect on particles deposition in the oral airway. The reduction of the airflow rate from 90 L/min to 30 L/min tripled the penetration efficiency of the MDI. A new experimental system has been employed to measure the particles deposition in the human airways. Expansion balloons were used to induce airflow as well as to collect the penetrated particles through an airway cast. The potential advantages of the balloon-based experimental system are simplicity, accuracy, and cost-effectiveness.
Ahmed Fadl; Jinbo Wang; Pao Yang; Zongqin Zhang; Yung Sung Cheng
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Inhalation toxicology     Volume:  19     ISSN:  1091-7691     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-14     Completed Date:  2007-08-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  505-15     Citation Subset:  IM    
Department of Mechanical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, USA.
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MeSH Terms
Aerosols / metabolism*
Equipment Design / instrumentation*,  methods,  standards*
Metered Dose Inhalers / standards*
Models, Biological*
Particle Size
Pulmonary Ventilation / physiology
Reg. No./Substance:

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