Document Detail


Balloon-based in vitro MDI aerosol deposition experiments on the effects of mouthpiece diameter.
MedLine Citation:
PMID:  17497529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For this article, we studied the effects of mouthpiece diameter and flow rate on aerosol penetration efficiency for metered-dose inhaler (MDI) applications. Measurements show that increasing the mouthpiece diameter has a moderate and positive influence on the particle penetration efficiency of the MDI. The particle penetration efficiency increases monotonically with the increase of the mouthpiece diameter from 16 mm to 20 mm. Second, the experiments show that airflow rate has an apparent and significant effect on particles deposition in the oral airway. The reduction of the airflow rate from 90 L/min to 30 L/min tripled the penetration efficiency of the MDI. A new experimental system has been employed to measure the particles deposition in the human airways. Expansion balloons were used to induce airflow as well as to collect the penetrated particles through an airway cast. The potential advantages of the balloon-based experimental system are simplicity, accuracy, and cost-effectiveness.
Authors:
Ahmed Fadl; Jinbo Wang; Pao Yang; Zongqin Zhang; Yung Sung Cheng
Related Documents :
8807759 - Prognostic significance of antenatally detected fetal pyelectasis.
957079 - Problems in using linear ultrasound parameters for the determination of fetal weight.
12164569 - Ultrasonographic nomograms of the fetal fourth ventricle: additional tool for detecting...
19386409 - Fetal volume and crown-rump length from 7 to 10 weeks of gestational age in singletons ...
15507979 - Clinical significance of first trimester crown-rump length disparity in dichorionic twi...
22229469 - Early procedure related complications of fetal blood sampling and intrauterine transfus...
9605249 - Mandibular arteriovenous malformation in pregnancy.
7819009 - Fetal renal maldevelopment with oligohydramnios following maternal use of piroxicam.
19163939 - Abdominal fetal ecg enhancement by event synchronous canceller.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Inhalation toxicology     Volume:  19     ISSN:  1091-7691     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-14     Completed Date:  2007-08-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  505-15     Citation Subset:  IM    
Affiliation:
Department of Mechanical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aerosols / metabolism*
Equipment Design / instrumentation*,  methods,  standards*
Metered Dose Inhalers / standards*
Models, Biological*
Particle Size
Pulmonary Ventilation / physiology
Chemical
Reg. No./Substance:
0/Aerosols

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Gas uptake in a three-generation model geometry with a flat inlet velocity during steady inspiration...
Next Document:  Comparison of particle tracking algorithms in commercial CFD packages: sedimentation and diffusion.