| Balancing protective immunity and immunopathology. | |
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MedLine Citation:
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PMID: 12088674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The immune system is fighting a constant war against pathogens in its own territory. This requires a potent arsenal for efficient control of pathogens but also requires tight regulatory mechanisms in order to avoid excessive collateral damage. Maintaining equilibrium is the daily challenge of the immune system. Interactions between pathogens, antigen-presenting cells (APCs) and lymphocytes are critical in this balancing act. Of particular importance for the generation of protective immune responses is the induction of activation programs in APCs directly by pathogens or by T cell derived factors, such as CD40L, RANKL or cytokines. In order to counterbalance overshooting immune responses, T cells and APCs secrete anti-inflammatory cytokines that are key for maintaining a healthy balance between protection and immunopathology. |
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Authors:
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Martin F Bachmann; Manfred Kopf |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in immunology Volume: 14 ISSN: 0952-7915 ISO Abbreviation: Curr. Opin. Immunol. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-06-28 Completed Date: 2002-11-07 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8900118 Medline TA: Curr Opin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 413-9 Citation Subset: IM |
Affiliation:
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Cytos Biotechnology AG, Wagistrasse 25, Zürich, Schlieren-Zürich, Switzerland. bachmann@cytos.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigen-Presenting Cells / immunology*, microbiology Cytokines / physiology Infection / immunology*, pathology Lymphocyte Activation Lymphocytes / immunology* Models, Immunological Phagocytosis Self Tolerance T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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