Document Detail


A Balancing Act: Mechanisms by which the fetus avoids rejection by thematernal immune system.
MedLine Citation:
PMID:  21389077     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Successful pregnancy requires strict temporal regulation of maternal immune function to accommodate the growing fetus. Early implantation is facilitated by inflammatory processes that ensure adequate vascular remodelling and placental invasion. To prevent rejection of the fetus, this inflammation must then be curtailed; reproductive immunologists are discovering that this process is orchestrated by the fetal unit, in particular the extravillous trophoblast. Soluble and particulate factors produced by the trophoblast regulate maternal immune cells within the decidua, as well as in the periphery. The aim of this review is to discuss the action of some of these recently discovered factors, and the potential effects of the dysregulation of such mechanisms on the maternal immune response that may result in pregnancy loss or preeclampsia.
Authors:
Julia C Warning; Sharon A McCracken; Jonathan M Morris
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-9
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  -     ISSN:  1741-7899     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
J Warning, Department of Perinatal Research, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, Australia.
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