Document Detail

Balanced terminal chromosome translocations develop in EBV-derived, but non-immortal cell lines from patients with mycosis fungoides.
MedLine Citation:
PMID:  3010616     Owner:  NLM     Status:  MEDLINE    
Five lymphoblastoid cell lines established from patients with mycosis fungoides were followed during long-term culture. They all expressed the Epstein-Barr virus nuclear antigen. Although the established B-cell lines initially showed a normal karyotype, metaphases with balanced terminal translocations gradually occurred. These chromosome abnormalities occurred simultaneously with decreased cell proliferation leading in all cases to termination of the cell lines. This contrasts the usual finding that Epstein-Barr virus established B-lymphoblastoid cell lines are immortal.
K Kaltoft; S Bisballe; K Rasmussen
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta dermato-venereologica. Supplementum     Volume:  120     ISSN:  0365-8341     ISO Abbreviation:  Acta Derm Venereol Suppl (Stockh)     Publication Date:  1985  
Date Detail:
Created Date:  1986-06-10     Completed Date:  1986-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370311     Medline TA:  Acta Derm Venereol Suppl (Stockh)     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  60-4     Citation Subset:  IM    
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MeSH Terms
B-Lymphocytes / pathology*
Cell Line
Cell Transformation, Viral*
Herpesvirus 4, Human*
Microscopy, Electron
Mycosis Fungoides / genetics,  pathology*
Skin / pathology*
Skin Neoplasms / genetics,  pathology*
Translocation, Genetic*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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