Document Detail

Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help.
MedLine Citation:
PMID:  15899919     Owner:  NLM     Status:  MEDLINE    
The production of high-affinity antibodies to T-dependent antigens requires the interaction of B cells and T helper cells expressing receptors specific for the same antigen. Although several mechanisms have been elucidated that regulate B-cell trafficking within lymphoid organs, less is known about molecular cues that guide the small subpopulation of CD4+ follicular T helper cells to B-cell follicles. Using adoptive transfer of transgenic T cells in mice, we demonstrate that antigen-induced activation leads to a finely tuned positioning of T cells either to the T-cell area or the B-cell follicle. We show that expression of CXCR5 is indispensable for T cells to enter B-cell follicles, whereas expression of CCR7 provides a counteracting signal to retain activated T cells in the T-cell area. Although only few T cells transiently migrate from the T-cell area to the B-cell follicle of peripheral lymph nodes following antigenic challenge, this step is essential to provide the help B cells require to produce antibodies efficiently. Thus, we demonstrate that the balanced expression of CCR7 and CXCR5 determines the positioning and proper function of follicular T helper cells.
Svenja Hardtke; Lars Ohl; Reinhold Förster
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-05-17
Journal Detail:
Title:  Blood     Volume:  106     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-05     Completed Date:  2005-10-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1924-31     Citation Subset:  AIM; IM    
Institute of Immunology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany.
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MeSH Terms
Adoptive Transfer
Antibody Formation / immunology
B-Lymphocytes / immunology*
Cell Communication / immunology
Chemotaxis, Leukocyte
Germinal Center / immunology*
Hemostasis / immunology*
Lymphocyte Activation
Mice, Knockout
Receptors, CCR7
Receptors, CXCR5
Receptors, Chemokine / genetics,  immunology,  physiology*
Receptors, Cytokine / genetics,  immunology,  physiology*
T-Lymphocytes / transplantation
T-Lymphocytes, Helper-Inducer / immunology,  physiology*
Reg. No./Substance:
0/Blr1 protein, mouse; 0/Ccr7 protein, mouse; 0/Receptors, CCR7; 0/Receptors, CXCR5; 0/Receptors, Chemokine; 0/Receptors, Cytokine

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