| The balance between initiation and promotion in radiation-induced murine carcinogenesis. | |
| | |
MedLine Citation:
|
PMID: 20726716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Studies of radiation carcinogenesis in animals allow detailed investigation of how the risk depends on age at exposure and time since exposure and of the mechanisms that determine this risk, e.g., induction of new pre-malignant cells (initiation) and enhanced proliferation of already existing pre-malignant cells (promotion). To assist the interpretation of these patterns, we apply a newly developed biologically based mathematical model to data on several types of solid tumors induced by acute whole-body radiation in mice. The model includes both initiation and promotion and analyzes pre-malignant cell dynamics on two different time scales: comparatively short-term during irradiation and long-term during the entire life span. Our results suggest general mechanistic similarities between radiation carcinogenesis in mice and in human atomic bomb survivors. The excess relative risk (ERR) in mice decreases with age at exposure up to an exposure age of 1 year, which corresponds to mid-adulthood in humans; the pattern for older ages at exposure, for which there is some evidence of increasing ERRs in atomic bomb survivors, cannot be evaluated using the data set analyzed here. Also similar to findings in humans, initiation dominates the ERR at young ages in mice, when there are few background pre-malignant cells, and promotion becomes important at older ages. |
| | |
Authors:
|
Igor Shuryak; Robert L Ullrich; Rainer K Sachs; David J Brenner |
Related Documents
:
|
20875196 - Murine models of premature ageing for the study of diet-induced immune changes: improve... 9008656 - Candidate biomarkers of aging: age-sensitive indices of immune and muscle function cova... 8153176 - Radial maze performance and open-field behaviours in aged c57bl/6 mice: further evidenc... 22074806 - Age-associated loss of selectivity in human olfactory sensory neurons. 7107936 - Locus of control and neuropsychological performance in chronic alcoholics. 22574866 - Five years later: resiliency among older adult survivors of hurricane katrina. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Radiation research Volume: 174 ISSN: 1938-5404 ISO Abbreviation: Radiat. Res. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-27 Completed Date: 2010-09-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: United States |
Other Details:
|
Languages: eng Pagination: 357-66 Citation Subset: IM; S |
Affiliation:
|
Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Transformation, Neoplastic Mice Neoplasms, Radiation-Induced / etiology* Risk |
| Grant Support | |
ID/Acronym/Agency:
|
U19-AI67773/AI/NIAID NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: cDNA Expression Analysis of a Human Radiosensitive-Radioresistant Cell Line Model Identifies Telomer...
Next Document: Preferential Decorporation of Americium by Pulmonary Administration of DTPA Dry Powder after Inhalat...