Document Detail


Baicalin protects human fibroblasts against ultraviolet B-induced cyclobutane pyrimidine dimers formation.
MedLine Citation:
PMID:  18401588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exposure to ultraviolet B (UVB) irradiation is a major risk factor for the development of skin cancer. Therefore, it is important to identify agents that can offer protection against UVB-caused DNA damage. Photocarcinogenesis is caused largely by mutations at the sites of incorrectly repaired DNA photoproducts, of which the most common are the cyclobutane pyrimidine dimers (CPDs). In this study, a DNA damage model of UVB irradiation-induced fibroblasts was established. The immunocytochemical staining, immuno dot blotting and Western blotting were employed in the study. We demonstrated that pre-treatment of fibroblasts with Baicalin dose-dependently reduced the amount of UVB-generated CPDs. Compared with UVB irradiated cells, UVB-induced p53 accumulation was less pronounced in Baicalin-treated cells. Taken together, these results suggest that Baicalin prevent CPDs formation induced by UVB. Baicalin is therefore a promising protective substance against UVB radiation.
Authors:
Bing-Rong Zhou; Dan Luo; Fang-Di Wei; Xiao-E Chen; Jie Gao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-10
Journal Detail:
Title:  Archives of dermatological research     Volume:  300     ISSN:  1432-069X     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-03     Completed Date:  2009-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  331-4     Citation Subset:  IM    
Affiliation:
Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. bingrong.2002@163.com
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MeSH Terms
Descriptor/Qualifier:
Cells, Cultured
Child, Preschool
DNA Damage / drug effects,  genetics,  radiation effects*
Dose-Response Relationship, Drug
Drugs, Chinese Herbal / pharmacology
Environmental Exposure / adverse effects
Fibroblasts / chemistry,  metabolism,  radiation effects*
Flavonoids / pharmacology*
Humans
Infant
Infant, Newborn
Male
Pyrimidine Dimers / chemistry,  genetics,  radiation effects*
Tumor Suppressor Protein p53 / antagonists & inhibitors,  genetics
Ultraviolet Rays / adverse effects
Chemical
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/Flavonoids; 0/Pyrimidine Dimers; 0/Tumor Suppressor Protein p53; 21967-41-9/baicalin

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