| Baicalin protects human fibroblasts against ultraviolet B-induced cyclobutane pyrimidine dimers formation. | |
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MedLine Citation:
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PMID: 18401588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exposure to ultraviolet B (UVB) irradiation is a major risk factor for the development of skin cancer. Therefore, it is important to identify agents that can offer protection against UVB-caused DNA damage. Photocarcinogenesis is caused largely by mutations at the sites of incorrectly repaired DNA photoproducts, of which the most common are the cyclobutane pyrimidine dimers (CPDs). In this study, a DNA damage model of UVB irradiation-induced fibroblasts was established. The immunocytochemical staining, immuno dot blotting and Western blotting were employed in the study. We demonstrated that pre-treatment of fibroblasts with Baicalin dose-dependently reduced the amount of UVB-generated CPDs. Compared with UVB irradiated cells, UVB-induced p53 accumulation was less pronounced in Baicalin-treated cells. Taken together, these results suggest that Baicalin prevent CPDs formation induced by UVB. Baicalin is therefore a promising protective substance against UVB radiation. |
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Authors:
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Bing-Rong Zhou; Dan Luo; Fang-Di Wei; Xiao-E Chen; Jie Gao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-10 |
Journal Detail:
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Title: Archives of dermatological research Volume: 300 ISSN: 1432-069X ISO Abbreviation: Arch. Dermatol. Res. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-03 Completed Date: 2009-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000462 Medline TA: Arch Dermatol Res Country: Germany |
Other Details:
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Languages: eng Pagination: 331-4 Citation Subset: IM |
Affiliation:
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Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. bingrong.2002@163.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cells, Cultured Child, Preschool DNA Damage / drug effects, genetics, radiation effects* Dose-Response Relationship, Drug Drugs, Chinese Herbal / pharmacology Environmental Exposure / adverse effects Fibroblasts / chemistry, metabolism, radiation effects* Flavonoids / pharmacology* Humans Infant Infant, Newborn Male Pyrimidine Dimers / chemistry, genetics, radiation effects* Tumor Suppressor Protein p53 / antagonists & inhibitors, genetics Ultraviolet Rays / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Drugs, Chinese Herbal; 0/Flavonoids; 0/Pyrimidine Dimers; 0/Tumor Suppressor Protein p53; 21967-41-9/baicalin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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