| Bafilomycins produced in culture by Streptomyces spp. isolated from marine habitats are potent inhibitors of autophagy. | |
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MedLine Citation:
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PMID: 20028134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Five new bafilomycins, F (1) to J (5), have been isolated from laboratory cultures of two Streptomyces spp. obtained from marine sediments collected in British Columbia, and their structures have been elucidated by detailed analysis of spectroscopic data and the synthesis of model compounds. The new bafilomycins F (1), G (2), H (3), and J (5) along with several co-occurring known analogues showed potent inhibition of autophagy in microscopy and biochemical assays. The thiomorpholinone fragment present in bafilomycin F (1) has not previously been found in a natural product. |
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Authors:
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Gavin Carr; David E Williams; Ana R D?az-Marrero; Brian O Patrick; Helen Bottriell; Aruna D Balgi; Elizabeth Donohue; Michel Roberge; Raymond J Andersen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of natural products Volume: 73 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-26 Completed Date: 2010-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 422-7 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of British Columbia, Vancouver, B.C., Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autophagy
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drug effects* British Columbia Macrolides / chemical synthesis, chemistry, isolation & purification*, pharmacology Marine Biology Models, Molecular Molecular Structure Nuclear Magnetic Resonance, Biomolecular Stereoisomerism Streptomyces / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Macrolides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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