| Bacteroides thetaiotaomicron in the gut: molecular aspects of their interaction. | |
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MedLine Citation:
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PMID: 17602905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The gut microflora can be considered a metabolically active organ composed of a vast and complex community of microorganisms that has an important role in the stability and functional activity of the intestinal ecosystem. Recently, thanks to microarray technology, a global screening of the microflora's regulated genes has allowed the analysis of the complex bacteria-host interplay. In particular, most of our knowledge comes from studies on Bacteroides thetaiotaomicron, a prominent member of the intestinal microflora of mice and humans. The results of published studies have revealed that Bacteroides thetaiotaomicron modulate the expression of a large quantity of genes implicated in different aspect of host physiology. This review aims to illustrate the specific contributions of this intestinal microorganism in three important aspects of host physiology: mucosal barrier reinforcement, immune system modulation and nutrients metabolism. In particular, we focus on recent insights about the molecular mechanisms by which Bacteroides thetaiotaomicron help the host in these important functions. |
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Authors:
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M A Zocco; M E Ainora; G Gasbarrini; A Gasbarrini |
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Publication Detail:
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Type: Journal Article; Review Date: 2007-06-29 |
Journal Detail:
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Title: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Volume: 39 ISSN: 1590-8658 ISO Abbreviation: Dig Liver Dis Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-19 Completed Date: 2007-10-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100958385 Medline TA: Dig Liver Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 707-12 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Catholic University of Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacteroides / genetics, physiology* DNA, Bacterial / genetics Genes, Bacterial / genetics Humans Immunity, Cellular / physiology Intestinal Mucosa / metabolism, microbiology Intestines / metabolism, microbiology* Symbiosis / physiology |
| Chemical | |
Reg. No./Substance:
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0/DNA, Bacterial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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