Document Detail


Bacteroides in the infant gut consume milk oligosaccharides via mucus-utilization pathways.
MedLine Citation:
PMID:  22036470     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Newborns are colonized with an intestinal microbiota shortly after birth, but the factors governing the retention and abundance of specific microbial lineages are unknown. Nursing infants consume human milk oligosaccharides (HMOs) that pass undigested to the distal gut, where they may be digested by microbes. We determined that the prominent neonate gut residents, Bacteroides thetaiotaomicron and Bacteroides fragilis, induce the same genes during HMO consumption that are used to harvest host mucus glycans, which are structurally similar to HMOs. Lacto-N-neotetraose, a specific HMO component, selects for HMO-adapted species such as Bifidobacterium infantis, which cannot use mucus, and provides a selective advantage to B. infantis in vivo when biassociated with B. thetaiotaomicron in the gnotobiotic mouse gut. This indicates that the complex oligosaccharide mixture within HMOs attracts both mutualistic mucus-adapted species and HMO-adapted bifidobacteria to the infant intestine that likely facilitate both milk and future solid food digestion.
Authors:
Angela Marcobal; Mariana Barboza; Erica D Sonnenburg; Nicholas Pudlo; Eric C Martens; Prerak Desai; Carlito B Lebrilla; Bart C Weimer; David A Mills; J Bruce German; Justin L Sonnenburg
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-10-27
Journal Detail:
Title:  Cell host & microbe     Volume:  10     ISSN:  1934-6069     ISO Abbreviation:  Cell Host Microbe     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-21     Completed Date:  2012-03-19     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  101302316     Medline TA:  Cell Host Microbe     Country:  United States    
Other Details:
Languages:  eng     Pagination:  507-14     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Data Bank Information
Bank Name/Acc. No.:
GEO/GSE26772;  GSE32207
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Bacteroides / genetics,  metabolism*
Breast Feeding
Gastrointestinal Tract / metabolism,  microbiology*
Humans
Mice
Milk / chemistry,  metabolism*
Milk, Human / chemistry,  metabolism
Mucus / metabolism*,  microbiology
Oligosaccharides / metabolism*
Polysaccharides / metabolism
Grant Support
ID/Acronym/Agency:
DK084214/DK/NIDDK NIH HHS; DP2 OD006515/OD/NIH HHS; DP2 OD006515/OD/NIH HHS; DP2 OD006515-01/OD/NIH HHS; IR01HD061923/HD/NICHD NIH HHS; R01 DK085025/DK/NIDDK NIH HHS; R01 DK085025/DK/NIDDK NIH HHS; R01 DK085025-03/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Oligosaccharides; 0/Polysaccharides
Comments/Corrections

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