| Bacteriovorax stolpii proliferation and predation without sphingophosphonolipids. | |
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MedLine Citation:
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PMID: 18086555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bacteriovorax stolpii strain UKi2, a facultative predator-parasite of larger Gram-negative bacteria, synthesizes distinct sphingophosphonolipids. These lipids are characterized by a direct P-C bond, the novel head group 1-hydroxy-2-aminoethylphosphonate, iso-branched long chain bases and fatty acids, and fatty acids dominated by those with alpha-hydroxy groups. Myriocin, an inhibitor of serine:fatty acyl CoA transferase, reversibly blocked sphingophosphonolipid synthesis in B. stolpii UKi2. However, the inhibitor did not block cell proliferation indicating that these lipids are not vital for B. stolpii UKi2 viability and growth. When mixed with Escherichia coli prey cells, control predator-parasite bacteria were effective in forming large E. coli bdelloplasts and cleared the suspension of the prey cells. Although myriocin-treated cells could attack prey cells and form bdelloplasts, their locomotory behavior was altered and fewer and smaller bdelloplasts were produced. These observations open up the possibility for a role of sphingophosphonolipids in B. stolpii UKi2 complex behavior. |
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Authors:
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Edna S Kaneshiro; Shannon M Hunt; Yoko Watanabe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-18 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 367 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-18 Completed Date: 2008-03-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 21-5 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, University of Cincinnati, 720 Rieveschl Hall, ML 0006, Cincinnati, OH 45221-0006, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Adhesion
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drug effects*,
physiology Bdellovibrio* / growth & development, metabolism Coenzyme A-Transferases / antagonists & inhibitors* Enzyme Inhibitors / pharmacology Escherichia coli / drug effects, physiology Fatty Acids, Monounsaturated / pharmacology* Models, Biological Phospholipids / chemistry*, metabolism Sphingolipids / chemistry*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Fatty Acids, Monounsaturated; 0/Phospholipids; 0/Sphingolipids; 35891-70-4/thermozymocidin; EC 2.8.3.-/Coenzyme A-Transferases |
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