Document Detail

Bacteriostatic and cytolytic activity of purple fluid from the sea hare.
MedLine Citation:
PMID:  2086268     Owner:  NLM     Status:  MEDLINE    
A bacteriostatic factor, aplysianin P, was purified from the purple fluid of a sea hare, Aplysia kurodai, as a glycoprotein of 60 K daltons. A cytolytic glycoprotein purified from the purple fluid of Dolabella auricularia did not show antibacterial activity. Aplysianin P was half-maximally active for gram-positive and -negative bacteria at 0.2-5.8 micrograms/mL and its action was not bactericidal but bacteriostatic. Aplysianin P completely inhibited the syntheses of DNA and RNA by E. coli, but it did not induce the release of ATP from bacteria. These results suggest that aplysianin P, found in an invertebrate, the sea hare, is a new bacteriostatic protein and that it exerts its action by inhibiting nucleic acid syntheses, as a DNA-inhibiting, chemotherapeutic drug does.
M Yamazaki; H Ohye; J Kisugi; H Kamiya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental and comparative immunology     Volume:  14     ISSN:  0145-305X     ISO Abbreviation:  Dev. Comp. Immunol.     Publication Date:  1990  
Date Detail:
Created Date:  1991-05-17     Completed Date:  1991-05-17     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7708205     Medline TA:  Dev Comp Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  379-83     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
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MeSH Terms
Anti-Bacterial Agents*
Aplysia / immunology
Bacteria / drug effects
Body Fluids / immunology
Cytotoxins / isolation & purification,  pharmacology
Glycoproteins / immunology*,  isolation & purification,  pharmacology
Mollusca / immunology*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Cytotoxins; 0/Glycopeptides; 0/Glycoproteins; 102510-57-6/aplysianin P

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