Document Detail

Bacteriophage cocktail significantly reduces Escherichia coli O157: H7 contamination of lettuce and beef, but does not protect against recontamination.
MedLine Citation:
PMID:  23275869     Owner:  NLM     Status:  Publisher    
Foods contaminated with Escherichia coli O157:H7 cause more than 63,000 foodborne illnesses in the United States every year, resulting in a significant economic impact on medical costs and product liabilities. Efforts to reduce contamination with E. coli O157:H7 have largely focused on washing, application of various antibacterial chemicals, and gamma-irradiation, each of which has practical and environmental drawbacks. A relatively recent, environmentally-friendly approach proposed for eliminating or significantly reducing E. coli O157:H7 contamination of foods is the use of lytic bacteriophages as biocontrol agents. We found that EcoShield™, a commercially available preparation composed of three lytic bacteriophages specific for E. coli O157:H7, significantly (p < 0.05) reduced the levels of the bacterium in experimentally contaminated beef by ≥ 94% and in lettuce by 87% after a five minute contact time. The reduced levels of bacteria were maintained for at least one week at refrigerated temperatures. However, the one-time application of EcoShield™ did not protect the foods from recontamination with E. coli O157:H7. Our results demonstrate that EcoShield™ is effective in significantly reducing contamination of beef and lettuce with E. coli O157:H7, but does not protect against potential later contamination due to, for example, unsanitary handling of the foods post processing.
Chandi D Carter; Adam Parks; Tamar Abuladze; Manrong Li; Joelle Woolston; Joshua Magnone; Andre Senecal; Andrew M Kropinski; Alexander Sulakvelidze
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Publication Detail:
Journal Detail:
Title:  Bacteriophage     Volume:  2     ISSN:  2159-7073     ISO Abbreviation:  Bacteriophage     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101556174     Medline TA:  Bacteriophage     Country:  -    
Other Details:
Languages:  ENG     Pagination:  178-185     Citation Subset:  -    
Intralytix, Inc.; Baltimore, MD USA.
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