| Bacteriophage cocktail significantly reduces Escherichia coli O157: H7 contamination of lettuce and beef, but does not protect against recontamination. | |
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MedLine Citation:
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PMID: 23275869 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Foods contaminated with Escherichia coli O157:H7 cause more than 63,000 foodborne illnesses in the United States every year, resulting in a significant economic impact on medical costs and product liabilities. Efforts to reduce contamination with E. coli O157:H7 have largely focused on washing, application of various antibacterial chemicals, and gamma-irradiation, each of which has practical and environmental drawbacks. A relatively recent, environmentally-friendly approach proposed for eliminating or significantly reducing E. coli O157:H7 contamination of foods is the use of lytic bacteriophages as biocontrol agents. We found that EcoShield™, a commercially available preparation composed of three lytic bacteriophages specific for E. coli O157:H7, significantly (p < 0.05) reduced the levels of the bacterium in experimentally contaminated beef by ≥ 94% and in lettuce by 87% after a five minute contact time. The reduced levels of bacteria were maintained for at least one week at refrigerated temperatures. However, the one-time application of EcoShield™ did not protect the foods from recontamination with E. coli O157:H7. Our results demonstrate that EcoShield™ is effective in significantly reducing contamination of beef and lettuce with E. coli O157:H7, but does not protect against potential later contamination due to, for example, unsanitary handling of the foods post processing. |
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Authors:
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Chandi D Carter; Adam Parks; Tamar Abuladze; Manrong Li; Joelle Woolston; Joshua Magnone; Andre Senecal; Andrew M Kropinski; Alexander Sulakvelidze |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Bacteriophage Volume: 2 ISSN: 2159-7073 ISO Abbreviation: Bacteriophage Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-12-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101556174 Medline TA: Bacteriophage Country: - |
Other Details:
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Languages: ENG Pagination: 178-185 Citation Subset: - |
Affiliation:
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Intralytix, Inc.; Baltimore, MD USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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