Document Detail

Bacteriocins: safe, natural antimicrobials for food preservation.
MedLine Citation:
PMID:  11764886     Owner:  NLM     Status:  MEDLINE    
Bacteriocins are antibacterial proteins produced by bacteria that kill or inhibit the growth of other bacteria. Many lactic acid bacteria (LAB) produce a high diversity of different bacteriocins. Though these bacteriocins are produced by LAB found in numerous fermented and non-fermented foods, nisin is currently the only bacteriocin widely used as a food preservative. Many bacteriocins have been characterized biochemically and genetically, and though there is a basic understanding of their structure-function, biosynthesis, and mode of action, many aspects of these compounds are still unknown. This article gives an overview of bacteriocin applications, and differentiates bacteriocins from antibiotics. A comparison of the synthesis. mode of action, resistance and safety of the two types of molecules is covered. Toxicity data exist for only a few bacteriocins, but research and their long-time intentional use strongly suggest that bacteriocins can be safely used.
J Cleveland; T J Montville; I F Nes; M L Chikindas
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  International journal of food microbiology     Volume:  71     ISSN:  0168-1605     ISO Abbreviation:  Int. J. Food Microbiol.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-17     Completed Date:  2001-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8412849     Medline TA:  Int J Food Microbiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-20     Citation Subset:  IM    
Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick 08901, USA.
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MeSH Terms
Anti-Bacterial Agents / biosynthesis,  chemistry,  classification,  pharmacology*
Bacteriocins / biosynthesis,  chemistry,  classification,  pharmacology*
Drug Resistance, Microbial
Food Preservation / methods*
Lactobacillus / metabolism*
Nisin / biosynthesis,  chemistry,  classification,  pharmacology
Structure-Activity Relationship
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Bacteriocins; 1414-45-5/Nisin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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