Document Detail

Bactericidal photoproducts in medium containing riboflavin plus aromatic compounds and MnCl2.
MedLine Citation:
PMID:  6349761     Owner:  NLM     Status:  MEDLINE    
Exposure to visible light of growth medium containing riboflavin and indole at low concentrations created photoproducts highly toxic to Salmonella typhimurium and other bacteria. No toxicity was detected in the dark or when either of these two components was present singly. Other aromatic compounds (serotonin, indole-3-acetic acid, indole-3-propionic acid, tryptophan, tyrosine, phenylalanine, and p-aminobenzoic acid) tested in place of indole produced various degrees of toxicity. The presence of MnCl2 significantly enhanced the toxicity. Addition of catalase eliminated the toxicity, indicating an important role for hydrogen peroxide.
C A Chelala; P Margolin
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of microbiology     Volume:  29     ISSN:  0008-4166     ISO Abbreviation:  Can. J. Microbiol.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-10-28     Completed Date:  1983-10-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372707     Medline TA:  Can J Microbiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  670-5     Citation Subset:  IM    
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MeSH Terms
Bacteria / drug effects*
Culture Media
Hydrogen Peroxide / pharmacology
Indoles / pharmacology*
Manganese / pharmacology*
Manganese Compounds*
Riboflavin / pharmacology*
Salmonella typhimurium / drug effects
Tryptophan / pharmacology
Reg. No./Substance:
0/Chlorides; 0/Culture Media; 0/Indoles; 0/Manganese Compounds; 73-22-3/Tryptophan; 7439-96-5/Manganese; 7722-84-1/Hydrogen Peroxide; 7773-01-5/manganese chloride; 83-88-5/Riboflavin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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