Document Detail


MedLine Citation:
PMID:  315746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bactericidal activity of three antibiotics, ampicillin, chloramphenicol and gentamicin, alone or in combinations, was determined against susceptible and resistant strains of Haemophilus influenzae. The various antibiotic combinations were studied for the determination of a synergistic or antagonistic effect. The study was done by the checkerboard method. A percentage of survivors inferior or equal to 0.01% of the inoculum represents the bactericidal activity. Ampicillin and chloramphenicol are bactericidal antibiotics against H. influenzae at concentrations of 1 microgram/ml and 4 microgram/ml, respectively. The combination of ampicillin and gentamicin exhibited a synergistic effect against strains sensitive and resistant to ampicillin. The combination of chloramphenicol and gentamicin was synergistic against all strains. Ampicillin and chloramphenicol, when combined, were antagonistic against two strains using a bacteriostatic concentration of chloramphenicol; and against the remaining strains the effects of the combination were indifferent.
Authors:
H J Dabernat; C Delmas; R Bauriaud; M B Lareng
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Annales de microbiologie     Volume:  130 A     ISSN:  0300-5410     ISO Abbreviation:  Ann. Microbiol. (Paris)     Publication Date:    1979 May-Jun
Date Detail:
Created Date:  1980-01-19     Completed Date:  1980-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0354704     Medline TA:  Ann Microbiol (Paris)     Country:  FRANCE    
Other Details:
Languages:  fre     Pagination:  469-79     Citation Subset:  IM    
Vernacular Title:
Activité bactéricide d'antibiotiques, isolés et en associations, sur des souches sensibles et résistantes de Haemophilus influenzae.
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MeSH Terms
Descriptor/Qualifier:
Ampicillin / pharmacology*
Chloramphenicol / pharmacology*
Drug Interactions
Gentamicins / pharmacology*
Haemophilus influenzae / drug effects*
Kinetics
Microbial Sensitivity Tests
Penicillin Resistance
Chemical
Reg. No./Substance:
0/Gentamicins; 56-75-7/Chloramphenicol; 69-53-4/Ampicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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