Document Detail

Bactericidal Action of Photo-irradiated Gallic Acid via Reactive Oxygen Species Formation.
MedLine Citation:
PMID:  22994545     Owner:  NLM     Status:  Publisher    
It is known that gallic acid shows antimicrobial activity. In the present study, photo-irradiation induced reactive oxygen species formation was investigated for augmentation of the antimicrobial activity of gallic acid. Staphylococcus aureus suspended in 4 mmol/L gallic acid was exposed to blue light of a LED at 400 nm. This treatment killed the bacteria, and a >5-log reduction of the viable counts was observed within 15 min. By contrast, neither the LED treatment alone nor the treatment with gallic acid alone showed substantial bactericidal effect. When hydroxyl radical scavengers were added to the suspension, the bactericidal effect of photo-irradiated gallic acid was attenuated. Furthermore, electron spin resonance analysis demonstrated that hydroxyl radicals were generated by the photo-irradiation of gallic acid. Thus, the present study suggests that the photo-oxidation can enhance the antimicrobial activity of gallic acid via hydroxyl radical formation.
Keisuke Nakamura; Yasutomo Yamada; Hiroyo Ikai; Taro Kanno; Keiichi Sasaki; Yoshimi Niwano
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-20
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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