| Bacterial virulence and inflammatory response in infants with febrile urinary tract infection or screening bacteriuria. | |
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MedLine Citation:
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PMID: 3279175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two populations were analyzed prospectively after a first episode of urinary tract infection. Asymptomatic infants were screened at 2 weeks and at 3 and 10 months of age, and bacteriuria was confirmed by bladder puncture. Infants with febrile urinary tract infection were enrolled during the same study period. The inflammatory response was characterized by the presence of fever, serum C-reactive protein, microsedimentation rate, urinary leukocyte excretion, and width of the ureters. The bacteria were defined for O:K:H serotype, hemolysin production, resistance to the bactericidal effect of serum, attachment to uroepithelial cells, and specificity for the globoseries of glycolipid receptors. In agreement with previous studies, the frequency of increased inflammatory signs and of attaching Escherichia coli was significantly higher in infants with febrile urinary tract infection than in the screening group. Within both patient groups, however, children infected with attaching E. coli strains had significantly more inflammatory signs. The results suggest that adherence facilitates the presentation of bacterial components capable of causing inflammation in the tissues in the urinary tract. |
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Authors:
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S Mårild; B Wettergren; M Hellström; U Jodal; K Lincoln; I Orskov; F Orskov; C Svanborg Edén |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pediatrics Volume: 112 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1988 Mar |
Date Detail:
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Created Date: 1988-04-14 Completed Date: 1988-04-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 348-54 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, University of Göteborg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Sedimentation C-Reactive Protein / analysis Escherichia coli / isolation & purification Female Fever / microbiology, physiopathology Humans Infant Infant, Newborn Inflammation / physiopathology Male Prospective Studies Urinary Tract Infections / microbiology, physiopathology* |
| Chemical | |
Reg. No./Substance:
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9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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