Document Detail

Bacterial virulence and inflammatory response in infants with febrile urinary tract infection or screening bacteriuria.
MedLine Citation:
PMID:  3279175     Owner:  NLM     Status:  MEDLINE    
Two populations were analyzed prospectively after a first episode of urinary tract infection. Asymptomatic infants were screened at 2 weeks and at 3 and 10 months of age, and bacteriuria was confirmed by bladder puncture. Infants with febrile urinary tract infection were enrolled during the same study period. The inflammatory response was characterized by the presence of fever, serum C-reactive protein, microsedimentation rate, urinary leukocyte excretion, and width of the ureters. The bacteria were defined for O:K:H serotype, hemolysin production, resistance to the bactericidal effect of serum, attachment to uroepithelial cells, and specificity for the globoseries of glycolipid receptors. In agreement with previous studies, the frequency of increased inflammatory signs and of attaching Escherichia coli was significantly higher in infants with febrile urinary tract infection than in the screening group. Within both patient groups, however, children infected with attaching E. coli strains had significantly more inflammatory signs. The results suggest that adherence facilitates the presentation of bacterial components capable of causing inflammation in the tissues in the urinary tract.
S Mårild; B Wettergren; M Hellström; U Jodal; K Lincoln; I Orskov; F Orskov; C Svanborg Edén
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  112     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-04-14     Completed Date:  1988-04-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  348-54     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Göteborg, Sweden.
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MeSH Terms
Blood Sedimentation
C-Reactive Protein / analysis
Escherichia coli / isolation & purification
Fever / microbiology,  physiopathology
Infant, Newborn
Inflammation / physiopathology
Prospective Studies
Urinary Tract Infections / microbiology,  physiopathology*
Reg. No./Substance:
9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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