Document Detail

Bacterial vaginosis and miscarriage.
MedLine Citation:
PMID:  15090889     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: This review aims to summarize current knowledge about the relationship between bacterial vaginosis and miscarriage. RECENT FINDINGS: Studies investigating the relationship between bacterial vaginosis and infertility, implantation and early pregnancy loss have produced conflicting results. One study demonstrated a beneficial effect of colonization with hydrogen peroxide producing lactobacilli. A community based study found no association between bacterial vaginosis and first trimester loss, but a positive association with early second trimester loss. In a randomized controlled trial, treatment of bacterial vaginosis with oral clindamycin was associated with a fivefold reduction in the incidence of late miscarriage. SUMMARY: The relationship between bacterial vaginosis and infertility and first trimester loss needs further elucidation. Measures to support a healthy lactobacillus flora such as probiotic therapy warrant study. The randomized controlled trials of clindamycin treatment need to be replicated in different settings.
Phillip E Hay
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in infectious diseases     Volume:  17     ISSN:  0951-7375     ISO Abbreviation:  Curr. Opin. Infect. Dis.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-05-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8809878     Medline TA:  Curr Opin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-4     Citation Subset:  IM    
Department of Genitourinary Medicine, St George's Hospital Medical School, London, UK.
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MeSH Terms
Abortion, Spontaneous / etiology*
Clindamycin / therapeutic use
Pregnancy Complications, Infectious*
Pregnancy Trimesters
Randomized Controlled Trials as Topic
Vaginosis, Bacterial / complications,  prevention & control*
Reg. No./Substance:

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