Document Detail

Bacterial-sized particle inflow through sutured clear corneal incisions in a laboratory human model.
MedLine Citation:
PMID:  21497050     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine the effectiveness of a single radial suture placement in 2 clear corneal incision (CCI) configurations in preventing inflow of bacterial-sized particles.
SETTING: Wilmer Eye Institute, Baltimore, Maryland, USA.
DESIGN: Experimental study.
METHODS: Ten human globes were used. Two 25-gauge needles connected to a saline solution bag and to a digital manometer were inserted through the limbus 120 degrees apart. Four incision-suture combinations were evaluated sequentially in each cornea. All incisions had the same dimensions (2.75 mm width, 3.00 mm length). Two incisions were single plane, and 2 were biplane. One incision from each configuration was left unsutured, and the other was sutured (10-0 nylon). With a preset 10 mm Hg intraocular pressure (IOP), India ink was applied to the incision site and a sudden IOP fluctuation was induced. Inflow was outlined and measured by planimetry.
RESULTS: There was a significant increase in area and linear distance of India-ink inflow after pressure challenge in all groups (P < .05), but with important differences among them. When the sutured and unsutured groups from each CCI were compared, there was a significantly smaller area of inflow in the 2-step unsutured group (P < .05). The linear inflow was higher in both sutured groups; however, the difference was significant for the 2-step incision configuration only (P < .05).
CONCLUSIONS: A single radial suture reduced the area of inflow of bacterial-sized particles but increased the linear distance of inflow in single-plane 3.0 mm incisions. Suture placement in a stepped incision increased inflow of bacterial-sized particles.
FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.
William N May; Juan Castro-Combs; Renata T Kashiwabuchi; Hans Hertzog; Woranart Tattiyakul; Yasin A Kahn; Flavio Hirai; Emily W Gower; Ashley Behrens
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-15
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  37     ISSN:  1873-4502     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-20     Completed Date:  2011-07-22     Revised Date:  2012-07-13    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1140-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
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MeSH Terms
Carbon / metabolism*
Cataract Extraction*
Cornea / metabolism*,  surgery*
Intraocular Pressure
Models, Biological
Surgical Wound Dehiscence / metabolism*
Suture Techniques*
Wound Healing / physiology
Reg. No./Substance:
0/Nylons; 0/chinese ink; 7440-44-0/Carbon
Comment In:
J Cataract Refract Surg. 2011 Dec;37(12):2235-6; author reply 2236-2237   [PMID:  22108133 ]
J Cataract Refract Surg. 2012 Jun;38(6):1117-8   [PMID:  22624932 ]

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