Document Detail


Bacterial shape: two-dimensional questions and possibilities.
MedLine Citation:
PMID:  20825347     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Events in the past decade have made it both possible and interesting to ask how bacteria create cells of defined length, diameter, and morphology. The current consensus is that bacterial shape is determined by the coordinated activities of cytoskeleton complexes that drive cell elongation and division. Cell length is most easily explained by the timing of cell division, principally by regulating the activity of the FtsZ protein. However, the question of how cells establish and maintain a specific and uniform diameter is, by far, much more difficult to answer. Mutations associated with the elongation complex often alter cell width, though it is not clear how. Some evidence suggests that diameter is strongly influenced by events during cell division. In addition, surprising new observations show that the bacterial cell wall is more highly malleable than previously believed and that cells can alter and restore their shapes by relying only on internal mechanisms.
Authors:
Kevin D Young
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annual review of microbiology     Volume:  64     ISSN:  1545-3251     ISO Abbreviation:  Annu. Rev. Microbiol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-09     Completed Date:  2010-12-13     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  0372370     Medline TA:  Annu Rev Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bacteria / cytology*,  metabolism*
Bacterial Physiological Phenomena*
Bacterial Proteins / metabolism
Cell Division
Cytoskeletal Proteins / metabolism
Cytoskeleton / metabolism
Gene Expression Regulation, Bacterial
Models, Biological
Grant Support
ID/Acronym/Agency:
R01 GM061019/GM/NIGMS NIH HHS; R01-GM061019/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Cytoskeletal Proteins; 0/FtsZ protein, Bacteria
Comments/Corrections

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