Document Detail


Bacterial sepsis secondary to platelet transfusion: an adverse effect of extended storage at room temperature.
MedLine Citation:
PMID:  3727014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a 3-month period four episodes of bacterial sepsis related to contaminated random donor platelet concentrates were observed. Evaluation incriminated extended (5 or more days) platelet storage. To determine if platelets stored for longer periods were likely to have greater bacterial contamination, platelet concentrates were inoculated with bacteria and daily quantitative bacteriology was performed. In vitro studies using polyolefin bags indicated contamination could occur with a single organism of Staphylococcus epidermidis. By 72 hours, platelet concentrates contained from 10(3) to 10(8) organisms per 0.1 ml depending on the inoculum size. By 6 days all inoculated units contained 10(7) to 10(9) organisms per 0.1 ml.
Authors:
H G Braine; T S Kickler; P Charache; P M Ness; J Davis; C Reichart; A K Fuller
Related Documents :
2170724 - Stimulation of oxygen consumption of platelets by solcoseryl and cardiocrome during in ...
8555634 - Biocompatible surfaces using methacryloylphosphorylcholine laurylmethacrylate copolymer.
10901594 - Filtered platelet concentrates from pooled buffy coats show comparable storage lesions ...
12823744 - Apoptotic markers are increased in platelets stored at 37 degrees c.
22293024 - Intraplatelet oxidative/nitrative stress: inductors, consequences, and control.
2168414 - Sodium fluoride prevents receptor- and protein kinase c-mediated activation of the huma...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transfusion     Volume:  26     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:    1986 Jul-Aug
Date Detail:
Created Date:  1986-08-11     Completed Date:  1986-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  391-3     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blood Preservation*
Blood Transfusion / adverse effects*
Corynebacterium Infections / etiology
Humans
Platelet Transfusion*
Sepsis / etiology*
Staphylococcal Infections / etiology
Staphylococcus epidermidis / growth & development
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Efficacy of plasma exchange in severe idiopathic rapidly progressive glomerulonephritis. A report of...
Next Document:  Mutagenicity of cyclosporine. Induction of sister chromatid exchange in human cells.