Document Detail


Bacterial modulation of small intestinal goblet cells and mucin composition during early posthatch development of poultry.
MedLine Citation:
PMID:  17954591     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mucins possess potential binding sites for both commensal and pathogenic organisms and may perform a defensive role during establishment of the intestinal barrier. To observe the effects of bacteria on intestinal goblet cell mucin production during posthatch development, differences in the small intestine of conventionally reared (CR) and low bacterial load (LBL) broiler chicks were examined. Jejunal and ileal goblet cells were stained with either periodic acid-Schiff stain or high iron diaminealcian blue pH 2.5 to discriminate among neutral, sulfated, and sialylated acidic mucins. Total goblet cell numbers and morphology of goblet cells containing neutral and acidic mucins did not differ significantly between CR and LBL birds. However, significant differences in acidic mucin composition from primarily sulfated to an increase in sialylated sugars at d 4 posthatch were observed in CR chicks, with greater numbers of jejunal and ileal goblet cells displaying this mucin type (CR, 0.5 +/- 0.1 x 10(3) cells/mm(2); LBL, 0.04 +/- 0.02 x10(3) cells/mm(2)). This change in mucin profile in response to bacterial colonization suggests a potential role as a protective mechanism against pathogenic invasion of the intestinal mucosa during early development.
Authors:
R E A Forder; G S Howarth; D R Tivey; R J Hughes
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Poultry science     Volume:  86     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-23     Completed Date:  2007-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2396-403     Citation Subset:  IM    
Affiliation:
Discipline of Agricultural and Animal Science, School of Agriculture, Food and Wine, University of Adelaide, Roseworthy, 5371, South Australia. rebecca.forder@adelaide.edu.au
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Animals, Newborn
Cell Count
Chickens / growth & development*,  microbiology*
Goblet Cells / cytology*,  microbiology*
Intestine, Small / cytology*,  growth & development
Mucins
Chemical
Reg. No./Substance:
0/Mucins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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