Document Detail


Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells.
MedLine Citation:
PMID:  25456122     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
It has long been speculated that metabolites, produced by gut microbiota, influence host metabolism in health and diseases. Here, we reveal that indole, a metabolite produced from the dissimilation of tryptophan, is able to modulate the secretion of glucagon-like peptide-1 (GLP-1) from immortalized and primary mouse colonic L cells. Indole increased GLP-1 release during short exposures, but it reduced secretion over longer periods. These effects were attributed to the ability of indole to affect two key molecular mechanisms in L cells. On the one hand, indole inhibited voltage-gated K(+) channels, increased the temporal width of action potentials fired by L cells, and led to enhanced Ca(2+) entry, thereby acutely stimulating GLP-1 secretion. On the other hand, indole slowed ATP production by blocking NADH dehydrogenase, thus leading to a prolonged reduction of GLP-1 secretion. Our results identify indole as a signaling molecule by which gut microbiota communicate with L cells and influence host metabolism.
Authors:
Catalin Chimerel; Edward Emery; David K Summers; Ulrich Keyser; Fiona M Gribble; Frank Reimann
Publication Detail:
Type:  Journal Article     Date:  2014-11-13
Journal Detail:
Title:  Cell reports     Volume:  9     ISSN:  2211-1247     ISO Abbreviation:  Cell Rep     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101573691     Medline TA:  Cell Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1202-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.
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