| Bacterial metabolism of para- and meta-xylene: oxidation of a methyl substituent. | |
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MedLine Citation:
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PMID: 4850727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pseudomonas Pxy was isolated on p-xylene as sole source of carbon and energy. Substrates that supported growth were toluene, p-methylbenzyl alcohol, p-tolualdehyde, p-toluic acid, and the analogous m-methyl derivatives, including m-xylene. Cell extracts prepared from Pseudomonas Pxy after growth with either p-xylene or m-xylene oxidized the p- and m-isomers of tolualdehyde as well as p-methylbenzyl alcohol. The same cell extracts also catalyzed a "meta" fission of both 3- and 4-methylcatechol. Treatment of Pseudomonas Pxy with N-methyl-N'-nitro-N-nitrosoguanidine led to the isolation of two mutant strains. Pseudomonas Pxy-40, when grown on succinate in the presence of p-xylene, accumulated p-toluic acid in the culture medium. Under the same conditions Pseudomonas Pxy-82 accumulated p-toluic acid and also 4-methylcatechol. When Pseudomonas Pxy-82 was grown on succinate in the presence of m-xylene, 3-methylcatechol and 3-methylsalicylic acid were excreted into the culture medium. A pathway is proposed for the initial reactions utilized by Pseudomonas Pxy to oxidize p- and m-xylene. |
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Authors:
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J F Davey; D T Gibson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of bacteriology Volume: 119 ISSN: 0021-9193 ISO Abbreviation: J. Bacteriol. Publication Date: 1974 Sep |
Date Detail:
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Created Date: 1974-11-12 Completed Date: 1974-11-12 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985120R Medline TA: J Bacteriol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 923-9 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Oxidoreductases
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metabolism Aldehyde Oxidoreductases / metabolism Benzoates / metabolism Catechols / biosynthesis, metabolism Cell-Free System Chemical Phenomena Chemistry Methylation Mutagens Mutation Nitrosoguanidines Oxidation-Reduction Oxygenases / metabolism Pseudomonas / enzymology, metabolism* Succinates / metabolism Toluene / metabolism Xylenes / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Benzoates; 0/Catechols; 0/Mutagens; 0/Nitrosoguanidines; 0/Succinates; 0/Xylenes; 108-88-3/Toluene; EC 1.1.-/Alcohol Oxidoreductases; EC 1.13.-/Oxygenases; EC 1.2.-/Aldehyde Oxidoreductases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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