Document Detail

Bacterial metabolic 'toxins': a new mechanism for lactose and food intolerance, and irritable bowel syndrome.
MedLine Citation:
PMID:  20851732     Owner:  NLM     Status:  MEDLINE    
Lactose and food intolerance cause a wide range of gut and systemic symptoms, including gas, gut pain, diarrhoea or constipation, severe headaches, severe fatigue, loss of cognitive functions such as concentration, memory and reasoning, muscle and joint pain, heart palpitations, and a variety of allergies (Matthews and Campbell, 2000; Matthews et al., 2005; Waud et al., 2008). These can be explained by the production of toxic metabolites from gut bacteria, as a result of anaerobic digestion of carbohydrates and other foods, not absorbed in the small intestine. These metabolites include alcohols, diols such as butan 2,3 diol, ketones, acids, and aldehydes such as methylglyoxal (Campbell et al., 2005, 2009). These 'toxins' induce calcium signals in bacteria and affect their growth, thereby acting to modify the balance of microflora in the gut (Campbell et al., 2004, 2007a,b). These bacterial 'toxins' also affect signalling mechanisms in cells around the body, thereby explaining the wide range of symptoms in people with food intolerance. This new mechanism also explains the most common referral to gastroenterologists, irritable bowel syndrome (IBS), and the illness that afflicted Charles Darwin for 50 years (Campbell and Matthews, 2005a,b). We propose it will lead to a new understanding of the molecular mechanism of type 2 diabetes and some cancers.
A K Campbell; S B Matthews; N Vassel; C D Cox; R Naseem; J Chaichi; I B Holland; J Green; K T Wann
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-09-18
Journal Detail:
Title:  Toxicology     Volume:  278     ISSN:  1879-3185     ISO Abbreviation:  Toxicology     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-03     Completed Date:  2011-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  268-76     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF103NB, UK.
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MeSH Terms
Bacteria / drug effects,  metabolism*
Bacterial Toxins / toxicity
Calcium Signaling / drug effects
Cell Proliferation / drug effects
Dietary Carbohydrates / metabolism,  toxicity*
Gastrointestinal Diseases / microbiology*
Gene Expression / drug effects
Irritable Bowel Syndrome / microbiology*
Lactose Intolerance / microbiology*
Pyruvaldehyde / toxicity
Reg. No./Substance:
0/Bacterial Toxins; 0/Dietary Carbohydrates; 78-98-8/Pyruvaldehyde

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