| Bacterial meningitis--an update. | |
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MedLine Citation:
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PMID: 1764875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report emphasizes new clinical information about bacterial meningitis in infants and children. Important elements of diagnosis include examination for the presence of shock and increased intracranial pressure. In such cases, initial treatment should focus on appropriate fluid therapy, administration of oxygen, reduction of intracranial pressure and use of corticosteroids. Currently, antibiotics of choice include ampicillin plus either cefotaxime or ceftriaxone in young infants, and one of these cephalosporins in older patients (beyond 3 months of age). Shorter durations of therapy (5 to 7 days for meningococcus, 7 days for haemophilus and 7-10 days for pneumococcus) are now commonly employed. In many centers, dexamethasone is started before the first dose of antibiotic and continued for 4 days to reduce neurologic and audiologic sequelae. Future trends will include studies of endotoxin neutralizers and non-steroidal anti-inflammatory drugs to reduce further tissue injury in meningitis. Prevention of meningitis is the ultimate goal. Since Haemophilus influenzae vaccination can now begin at 2 months, this approach may bring important results soon. |
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Authors:
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M I Marks |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical pediatrics Volume: 30 ISSN: 0009-9228 ISO Abbreviation: Clin Pediatr (Phila) Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-02-20 Completed Date: 1992-02-20 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0372606 Medline TA: Clin Pediatr (Phila) Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 673-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, University of California, Irvine. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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therapeutic use* Child Dexamethasone / therapeutic use Humans Infant Meningitis, Bacterial* / diagnosis, therapy Meningitis, Haemophilus / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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