| Bacterial meningitis: is there a "best" antimicrobial therapy? | |
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MedLine Citation:
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PMID: 3297707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The introduction of several cephalosporins into pediatric practice has provided the physician with a number of choices in the treatment of neonatal and childhood meningitis. Adequate studies are available to indicate that these new drugs are as effective as traditional treatments in terms of survival and major neurologic sequelae but it is not known whether the results are worse or better as far as the incidence of more subtle neurologic changes is concerned. The advantages of the cephalosporins in treatment of childhood meningitis are that they permit single drug therapy, the risks of drug toxicity are reduced, and the problems of penicillin-tolerant pneumococci and ampicillin/chloramphenicol-resistant H. influenzae are avoided. When used in the treatment of neonatal disease, the cephalosporins have the advantage of lower toxicity than the aminoglycosides, generally making blood drug level determinations unnecessary, and are effective against strains of bacteria that have become resistant to the latter drugs. |
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Authors:
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H F Eichenwald |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pediatrics Volume: 146 ISSN: 0340-6199 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 1987 May |
Date Detail:
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Created Date: 1987-07-28 Completed Date: 1987-07-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 216-20 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cefoperazone
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therapeutic use Ceftazidime / therapeutic use Ceftriaxone / therapeutic use Cefuroxime / therapeutic use Cephalosporins / therapeutic use* Child Humans Infant, Newborn Meningitis / drug therapy* Meningitis, Haemophilus / drug therapy* Moxalactam / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Cephalosporins; 55268-75-2/Cefuroxime; 62893-19-0/Cefoperazone; 64952-97-2/Moxalactam; 73384-59-5/Ceftriaxone; 78439-06-2/Ceftazidime |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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