| Bacterial lipopolysaccharide enhances cardiac dysfunction but not retroviral replication in murine AIDS: roles of macrophage infiltration and toll-like receptor 4 expression. | |
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MedLine Citation:
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PMID: 16507888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiovascular disease is an important complication of human immunodeficiency virus/acquired immune deficiency syndrome (AIDS), but the mechanism(s) involved are poorly understood. Although co-infecting pathogens have been implicated as an important factor in AIDS progression, no studies have investigated these interactions in cardiac tissue. We recently demonstrated that the murine AIDS model (LPBM5 retroviral infection) mimics human immunodeficiency virus-related cardiac dysfunction and pathology. We tested the hypothesis that subseptic lipopolysaccharide exposure (LPS) would enhance LPBM5 progression and exacerbate cardiovascular dysfunction during murine AIDS development. LPS (5 mg/kg, Escherichia coli 0111:B4) was administered at 1, 6, and 8 weeks during LPBM5 infection, and cardiac performance was evaluated at 10 weeks using noninvasive echocardiography. LPS alone had no significant effects, whereas it amplified abnormalities in cardiac structure and function observed in murine AIDS. Cardiac dysfunction was associated with selective increases in nonfocal infiltration of CD68(+) cells and correlated with the extent of cardiac dysfunction. Retroviral progression and cardiac retroviral content remained unaltered, but cardiac toll-like receptor 4 was increased in retrovirus + LPS. We provide first-time evidence of multipathogen enhancements to retrovirus-related cardiac complications and implicate innate immune responses, not co-pathogen-induced retroviral replication, as the primary mechanism in this setting. |
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Authors:
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Alysia A Chaves; Reshma S Baliga; Michael J Mihm; Brandon L Schanbacher; Anupam Basuray; Cynthia Liu; Angela C Cook; Leona W Ayers; John Anthony Bauer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The American journal of pathology Volume: 168 ISSN: 0002-9440 ISO Abbreviation: Am. J. Pathol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-01 Completed Date: 2006-04-19 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 727-35 Citation Subset: AIM; IM |
Affiliation:
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Center for Cardiovascular Medicine, Columbus Children's Research Institute, 700 Children's Dr., Columbus, OH 43205, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications*,
virology Animals Antigens, CD / analysis Antigens, Differentiation, Myelomonocytic / analysis Cardiomyopathies / immunology*, pathology, physiopathology Disease Models, Animal Heart / physiopathology Immunohistochemistry Leukocytes / immunology Lipopolysaccharides / toxicity* Macrophages / immunology* Mice Myocardium / chemistry, pathology Retroviridae / physiology Toll-Like Receptor 4 / analysis, genetics, metabolism* Virus Replication / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL-59791/HL/NHLBI NIH HHS; HL-63067/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 protein, mouse; 0/Lipopolysaccharides; 0/Toll-Like Receptor 4 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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