Document Detail

Bacterial killing by dry metallic copper surfaces.
MedLine Citation:
PMID:  21148701     Owner:  NLM     Status:  MEDLINE    
Metallic copper surfaces rapidly and efficiently kill bacteria. Cells exposed to copper surfaces accumulated large amounts of copper ions, and this copper uptake was faster from dry copper than from moist copper. Cells suffered extensive membrane damage within minutes of exposure to dry copper. Further, cells removed from copper showed loss of cell integrity. Acute contact with metallic copper surfaces did not result in increased mutation rates or DNA lesions. These findings are important first steps for revealing the molecular sensitive targets in cells lethally challenged by exposure to copper surfaces and provide a scientific explanation for the use of copper surfaces as antimicrobial agents for supporting public hygiene.
Christophe Espírito Santo; Ee Wen Lam; Christian G Elowsky; Davide Quaranta; Dylan W Domaille; Christopher J Chang; Gregor Grass
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-12-10
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  77     ISSN:  1098-5336     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-28     Completed Date:  2011-05-26     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  794-802     Citation Subset:  IM    
Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, and Marine and Environmental Research Center (IMAR-CMA), 3001-401 Coimbra, Portugal.
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MeSH Terms
Anti-Infective Agents
Bacillus cereus / drug effects*,  growth & development
Bacteria / drug effects,  growth & development
Cell Membrane / drug effects
Copper / metabolism,  toxicity*
Deinococcus / drug effects*,  growth & development
Escherichia coli / drug effects*,  growth & development
Microbial Viability / drug effects
Grant Support
P20 RR-017675/RR/NCRR NIH HHS; //Howard Hughes Medical Institute
Reg. No./Substance:
0/Anti-Infective Agents; 7440-50-8/Copper

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