Document Detail


Bacterial invasion of the biliary system by way of the portal-venous system.
MedLine Citation:
PMID:  1860688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been suggested that bacteria in the intestine gain access into the biliary tract by entering the portal-venous blood. We have tested the hypothesis of hematogenous infection of the biliary system in cats. The animals were treated in three different groups: group A (no biliary obstruction), group B (acute biliary obstruction) and group C (chronic biliary obstruction). A mutant strain of Escherichia coli was infused into the splenic vein of cats at three different dosages (10(7), 10(5) and 10(3) with sham controls. In the unobstructed biliary system, the mutant E. coli was isolated from the bile 30 min and 90 min after the infusion of 10(7) and 10(5) E. coli, respectively. No bacteria were found in the bile with the infusion of 10(3) E. coli and in the control animals. Bile flow was significantly reduced with the infusion of bacteria. The biliary excretion of E. coli in group B was similar to that in group A. In group C, the bile output in the first hour was very high but declined rapidly. E. coli was excreted into the bile at all three dosages of infusion after 30 min. Histological sections of the liver showed that the infused bacteria entered the sinusoidal blood and that some were phagocytosed by Kupffer cells. The portal-venous blood was considered an important route of bacterial invasion into the biliary system, and the penetration of bacteria was facilitated in biliary obstruction.
Authors:
J Y Sung; E A Shaffer; M E Olson; J W Leung; K Lam; J W Costerton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  14     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-08-30     Completed Date:  1991-08-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  313-7     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, University of Calgary, Alberta, Canada.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Bacteria / isolation & purification*
Bacterial Physiological Phenomena
Biliary Tract / microbiology*
Biliary Tract Diseases / microbiology
Blood / microbiology*
Cats
Chronic Disease
Colony Count, Microbial
Portal Vein*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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