Document Detail

Bacterial infections of the small intestine.
MedLine Citation:
PMID:  23380575     Owner:  NLM     Status:  In-Data-Review    
PURPOSE OF REVIEW: The purpose of this study is to summarize the recent developments in small intestinal bacterial infections.
RECENT FINDINGS: This review focuses on aspects of intestinal bacterial infection concerning research developments related to pathogenesis, new therapeutic agents and approaches, as well as potential new vaccine targets.
SUMMARY: In terms of drug utilization, azithromycin was successfully used to eradicate a Shiga toxin producing Escherichia coli (enterohemorrhagic E. coli) without harmful effects. In the case of Clostridium difficile, fidaxomicin was found to be comparable to or superior to vancomycin depending on study conditions and whether there was concomitant antibiotic use. A novel research finding is the role of galectin 8, which is a danger-sensing lectin, which plays a role in targeting Salmonella for autophagy. In addition, several enteropathogenic E. coli and Shigella effectors were found to inactivate members of the nuclear factor kappa B pathway.
Kim Hodges; Gail Hecht
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in gastroenterology     Volume:  29     ISSN:  1531-7056     ISO Abbreviation:  Curr. Opin. Gastroenterol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506887     Medline TA:  Curr Opin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  159-63     Citation Subset:  IM    
aDepartment of Digestive Disease and Nutrition, University of Illinois at Chicago bJesse Brown VA, Chicago, Illinois, USA.
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