Document Detail

Bacterial infections associated with hepatic encephalopathy: prevalence and outcome.
MedLine Citation:
PMID:  15094705     Owner:  NLM     Status:  MEDLINE    
Hepatic encephalopathy (HE) is a major sign of severe liver disease and the impact of associated bacterial infections should be better evaluated. A retrospective cohort of 333 patients with cirrhosis and HE was analyzed in three periods of time, from 1984 to 1998. Variance analysis, Wilcoxon, Chi-square and Fisher's exact tests were used for statistical comparisons. Prevalence of bacterial infections decreased along the time (p = 0.0029). Spontaneous Bacterial Peritonitis -SBP- (37%) and urinary tract infection (30%) were the more frequent types of bacterial infections. Early death was significantly higher in HE with infection (46,47%) and the calculated RR was 2.047. Prognosis was worse in septicemia (79%) and respiratory tract infection (50%) and better in urinary tract infection (27%). SBP lethality was reduced from 70% to 38% (p = 0.062). In conclusion, lower prevalence of bacterial infections, in severe liver disease, was achieved in the last decade, but short-term prognosis remains bad, varying according to the type of bacterial infection.
Edna Strauss; Maria de Fátima Gomes de Sá Ribeiro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of hepatology     Volume:  2     ISSN:  1665-2681     ISO Abbreviation:  Ann Hepatol     Publication Date:    2003 Jan-Mar
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-06-08     Revised Date:  2013-05-16    
Medline Journal Info:
Nlm Unique ID:  101155885     Medline TA:  Ann Hepatol     Country:  Mexico    
Other Details:
Languages:  eng     Pagination:  41-5     Citation Subset:  IM    
Clinic of Gastroenterology, Heliopólis Hospital; School of Medicine-University of Säo Paulo, Av. Dr. Eneas de CArvalho Aguiar, 177-10o andar, CEP: 05403-000 Säo Paulo, Brazil.
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MeSH Terms
Aged, 80 and over
Bacterial Infections / complications*,  epidemiology
Hepatic Encephalopathy / complications,  microbiology*,  mortality
Liver Cirrhosis / complications,  microbiology*,  mortality
Middle Aged
Peritonitis / complications,  microbiology
Respiratory Tract Infections / complications,  microbiology
Severity of Illness Index
Urinary Tract Infections / complications,  microbiology

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