Document Detail

Bacterial hydrogen peroxide contributes to cerebral hyperemia during early stages of experimental pneumococcal meningitis.
MedLine Citation:
PMID:  17311075     Owner:  NLM     Status:  MEDLINE    
Alterations of blood flow contribute to major clinical complications in invasive infections such as sepsis and bacterial meningitis. As a unique feature streptococci -- in particular, Streptococcus pneumoniae, the most frequent pathogen in bacterial meningitis -- release hydrogen peroxide (H(2)O(2)) because of the absence of functional catalase. In a 6 h rat model of experimental meningitis, we studied the impact of bacterial H(2)O(2) production on regional cerebral blood flow (rCBF) and intracranial pressure (ICP). Compared to wild-type D39 pneumococci, the increase of rCBF was diminished in meningitis induced by the H(2)O(2) defective SpxB(-) mutant (maximum increase, 135% +/- 17% versus 217% +/- 23% of the individual baseline; P<0.01) or after treatment of D39-induced meningitis with H(2)O(2)-degrading catalase or with tetraethylammonium (TEA), a blocker of calcium-sensitive potassium channels, which mediate H(2)O(2)-induced vasodilation. Catalase did not significantly reduce the remaining rCBF increase caused by SpxB(-), supporting the predominant role of bacterial H(2)O(2). We conclude that in addition to host-sided mediators, bacterial-derived H(2)O(2) acts as a potent vasodilator, which accounts for a certain proportion of the early cerebral hyperperfusion in pneumococcal meningitis.
Olaf M Hoffmann; Doreen Becker; Joerg R Weber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-21
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  27     ISSN:  0271-678X     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-23     Completed Date:  2007-11-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1792-7     Citation Subset:  IM    
Department of Experimental Neurology, Center for Anatomy, Charité-Universitaetsmedizin Berlin, Berlin, Germany.
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MeSH Terms
Antioxidants / pharmacology
Blood Pressure / drug effects,  physiology
Catalase / pharmacology
Cerebrovascular Circulation / drug effects,  physiology*
Hydrogen Peroxide / metabolism*
Hyperemia / microbiology,  physiopathology*
Intracranial Pressure / drug effects,  physiology
Meningitis, Pneumococcal / metabolism*,  microbiology,  physiopathology*
Rats, Wistar
Streptococcus pneumoniae / metabolism*
Tetraethylammonium / pharmacology
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Antioxidants; 0/Vasodilator Agents; 66-40-0/Tetraethylammonium; 7722-84-1/Hydrogen Peroxide; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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