Document Detail

Bacterial exploitation of host cell signaling.
MedLine Citation:
PMID:  20881278     Owner:  NLM     Status:  MEDLINE    
As a way of enhancing infections, bacterial pathogens often alter host cell signaling pathways. Here, we describe recent work that highlights a new phosphatase from an intestinal and wound-invading pathogen that manipulates host cell phosphoinositide circuits. Despite the active-site homology between bacterial inositol phosphatases and mammalian phosphatases, sequence differences between them suggest that the development of specific inhibitors may be feasible.
Richard Lu; Marcia B Goldberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science translational medicine     Volume:  2     ISSN:  1946-6242     ISO Abbreviation:  Sci Transl Med     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-30     Completed Date:  2011-03-10     Revised Date:  2014-05-01    
Medline Journal Info:
Nlm Unique ID:  101505086     Medline TA:  Sci Transl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  51ps48     Citation Subset:  IM    
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MeSH Terms
Bacteria / metabolism*
Cells / metabolism*,  microbiology*
Host-Pathogen Interactions*
Signal Transduction*
Grant Support

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