| Bacterial effectors: learning on the fly. | |
| | |
MedLine Citation:
|
PMID: 22127883 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
A common defining characteristic of pathogenic bacteria is the expression of a repertoire of effector molecules that have been named virulence factors. These bacterial factors include a -variety of proteins, such as toxins that are internalized by receptors and translocate across endosomal membranes to reach the cytosol, as well as others that are introduced directly into the cell by means of bacterial secretory apparatuses. Given the importance of these effectors for understanding bacterial pathogenicity, significant effort has been made to dissect their molecular mechanisms of action and their respective roles during infection. Herein we will discuss how Drosophila have been used as a model system to study these important microbial effectors, and to understand their contribution to pathogenicity. |
| | |
Authors:
|
Laurent Boyer; Nicholas Paquette; Neal Silverman; Lynda M Stuart |
Related Documents
:
|
18380473 - Predominant release of lysosomal enzymes by newborn rat microglia after lps treatment r... 12106813 - Cholesterol, oxidative stress, and alzheimer's disease: expanding the horizons of patho... 4140273 - Pathogenesis of lipoid nephrosis: a disorder of t-cell function. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Advances in experimental medicine and biology Volume: 710 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2012 |
Date Detail:
|
Created Date: 2011-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 29-36 Citation Subset: IM |
Affiliation:
|
INSERM, U895, Centre Méditerranéen de Médecine Moléculaire, Toxines Microbiennes dans la relation hôte pathogènes, Cedex 3, F-06204, Nice, France, laurent.boyer@unice.fr. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Caenorhabditis elegans as an Alternative Model to Study Senescence of Host Defense and the Preventio...
Next Document: A Drosophila asthma model - what the fly tells us about inflammatory diseases of the lung.