| Bacterial deconjugation of arbutin by Escherichia coli. | |
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MedLine Citation:
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PMID: 12807345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RESULTS: In comparison to incubation with glusulase the E. coli-suspension resulted in a 2.3 fold higher increase in free hydroquinone. When separating bacteria from the urine, the hydroquinone concentration in bacteria was 20 fold higher than in the supernatant. CONSEQUENCES: Glucuronic acid or sulfuric acid conjugates of hydroquinones obviously are taken up, enriched and metabolized to hydroquinone by bacteria. Deconjugation of hydroquinone likely is catalyzed by intracellular enzymes presumably present in bacterial cytoplasm; comparable activities in eucaryotic cells usually are localized in lysosomes. Alkalization of the urine seems not to be a prerequisite to improve the antiseptic properties of hydroquinone released from arbutin. |
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Authors:
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Claudia Siegers; Cornelia Bodinet; Sawar Syed Ali; Claus-Peter Siegers |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Phytomedicine : international journal of phytotherapy and phytopharmacology Volume: 10 Suppl 4 ISSN: 0944-7113 ISO Abbreviation: Phytomedicine Publication Date: 2003 |
Date Detail:
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Created Date: 2003-06-16 Completed Date: 2003-08-14 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 9438794 Medline TA: Phytomedicine Country: Germany |
Other Details:
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Languages: eng Pagination: 58-60 Citation Subset: IM |
Affiliation:
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Institute of Experimental and Clinical Pharmacology and Toxicology, University of Luebeck, Luebeck, Germany. siegers@medinf.mu-luebeck.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arbutin / pharmacokinetics, pharmacology*, urine Arctostaphylos* Escherichia coli / drug effects*, metabolism Female Humans Hydroquinones / urine Male Middle Aged Phytotherapy* Plant Extracts / pharmacokinetics, pharmacology, urine |
| Chemical | |
Reg. No./Substance:
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0/Hydroquinones; 0/Plant Extracts; 497-76-7/Arbutin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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