Document Detail

Bacterial deconjugation of arbutin by Escherichia coli.
MedLine Citation:
PMID:  12807345     Owner:  NLM     Status:  MEDLINE    
RESULTS: In comparison to incubation with glusulase the E. coli-suspension resulted in a 2.3 fold higher increase in free hydroquinone. When separating bacteria from the urine, the hydroquinone concentration in bacteria was 20 fold higher than in the supernatant.
CONSEQUENCES: Glucuronic acid or sulfuric acid conjugates of hydroquinones obviously are taken up, enriched and metabolized to hydroquinone by bacteria. Deconjugation of hydroquinone likely is catalyzed by intracellular enzymes presumably present in bacterial cytoplasm; comparable activities in eucaryotic cells usually are localized in lysosomes. Alkalization of the urine seems not to be a prerequisite to improve the antiseptic properties of hydroquinone released from arbutin.
Claudia Siegers; Cornelia Bodinet; Sawar Syed Ali; Claus-Peter Siegers
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  10 Suppl 4     ISSN:  0944-7113     ISO Abbreviation:  Phytomedicine     Publication Date:  2003  
Date Detail:
Created Date:  2003-06-16     Completed Date:  2003-08-14     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  58-60     Citation Subset:  IM    
Institute of Experimental and Clinical Pharmacology and Toxicology, University of Luebeck, Luebeck, Germany.
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MeSH Terms
Arbutin / pharmacokinetics,  pharmacology*,  urine
Escherichia coli / drug effects*,  metabolism
Hydroquinones / urine
Middle Aged
Plant Extracts / pharmacokinetics,  pharmacology,  urine
Reg. No./Substance:
0/Hydroquinones; 0/Plant Extracts; 497-76-7/Arbutin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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