Document Detail


Bacterial colonization of Hemasite access devices.
MedLine Citation:
PMID:  3082026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vascular access ports (Hemasites) were recovered from patients in whom they had become foci of infection and were examined according to microbiologic and morphologic techniques. All were covered on their extraluminal surfaces by well-developed biofilms consisting of host material and bacteria and their extracellular products. One Hemasite from which Staphylococcus aureus and Streptococcus faecalis were cultured was covered by a biofilm that consisted of coccoid bacterial cells and occasional fungal cells. Another Hemasite from which Proteus mirabilis was cultured was covered by a polymicrobial biofilm consisting of at least six morphologically distinct bacterial types and their extracellular products. This direct observation of the biofilm mode of bacterial growth on these devices suggests that the colonizing organisms will not be completely recovered by routine microbiologic techniques and that bacteria in the biofilm will tend to resist both host clearance mechanisms and antibiotic therapy. Removal of the device, with its accretion of bacterial biofilm, should allow the resolution of the associated infection.
Authors:
W P Reed; M R Moody; K A Newman; P D Light; J W Costerton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery     Volume:  99     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-04-04     Completed Date:  1986-04-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  308-17     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Arteriovenous Shunt, Surgical / adverse effects,  instrumentation*
Bacterial Infections / etiology*
Brachial Artery
Enterococcus faecalis / isolation & purification
Escherichia coli / isolation & purification
Humans
Klebsiella pneumoniae / isolation & purification
Microscopy, Electron, Scanning
Polytetrafluoroethylene*
Proteus mirabilis / isolation & purification
Staphylococcus aureus / isolation & purification
Staphylococcus epidermidis / isolation & purification
Surgical Wound Infection / etiology
Titanium
Chemical
Reg. No./Substance:
7440-32-6/Titanium; 9002-84-0/Polytetrafluoroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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