| Bacterial cell wall products increases stabilization of HIF-1 alpha in an oligodendrocyte cell line preconditioned by cobalt chloride or desferrioxamine. | |
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MedLine Citation:
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PMID: 18715655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the effect of lipopolysaccharide (LPS) or lipotechoic acid (LTA) on the regulation of hypoxia inducible factor (HIF-1) alpha on the MO3.13 cells, a human oligodendroglial cell line. Our study shows that MO3.13 cells express the toll like receptors (TLR's) but do not increase cellular levels of HIF-1 alpha following exposure to bacterial cell wall products. When MO3.13 cells were preconditioned by desferrioxamine (DFO) or cobalt chloride (CoCl(2)) and then treated with either LPS or LTA, HIF-1 alpha levels were higher than that induced by DFO or CoCl(2) alone. The increase in HIF-1 alpha was due to increased protein stability that was mediated by activation of the ERK-MAP kinase pathway. |
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Authors:
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Song-yi Yao; Mohammed Soutto; Subramaniam Sriram |
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Publication Detail:
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Type: Journal Article Date: 2008-08-20 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 200 ISSN: 0165-5728 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-29 Completed Date: 2008-12-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 17-26 Citation Subset: IM |
Affiliation:
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Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antimutagenic Agents
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pharmacology* Bacteria / cytology Cell Line, Transformed Cell Wall / chemistry Cobalt / pharmacology* Deferoxamine / pharmacology* Dose-Response Relationship, Drug Drug Interactions Gene Expression Regulation / drug effects* Humans Hypoxia-Inducible Factor 1, alpha Subunit / genetics, metabolism* Lipopolysaccharides / pharmacology Oligodendroglia / drug effects* Siderophores / pharmacology* Teichoic Acids / pharmacology Time Factors Toll-Like Receptors / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antimutagenic Agents; 0/HIF1A protein, human; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/Lipopolysaccharides; 0/Siderophores; 0/Teichoic Acids; 0/Toll-Like Receptors; 56411-57-5/lipoteichoic acid; 70-51-9/Deferoxamine; 7440-48-4/Cobalt; 7646-79-9/cobaltous chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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