Document Detail

Bacterial cell wall products increases stabilization of HIF-1 alpha in an oligodendrocyte cell line preconditioned by cobalt chloride or desferrioxamine.
MedLine Citation:
PMID:  18715655     Owner:  NLM     Status:  MEDLINE    
We examined the effect of lipopolysaccharide (LPS) or lipotechoic acid (LTA) on the regulation of hypoxia inducible factor (HIF-1) alpha on the MO3.13 cells, a human oligodendroglial cell line. Our study shows that MO3.13 cells express the toll like receptors (TLR's) but do not increase cellular levels of HIF-1 alpha following exposure to bacterial cell wall products. When MO3.13 cells were preconditioned by desferrioxamine (DFO) or cobalt chloride (CoCl(2)) and then treated with either LPS or LTA, HIF-1 alpha levels were higher than that induced by DFO or CoCl(2) alone. The increase in HIF-1 alpha was due to increased protein stability that was mediated by activation of the ERK-MAP kinase pathway.
Song-yi Yao; Mohammed Soutto; Subramaniam Sriram
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Publication Detail:
Type:  Journal Article     Date:  2008-08-20
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  200     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-29     Completed Date:  2008-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  17-26     Citation Subset:  IM    
Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA.
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MeSH Terms
Antimutagenic Agents / pharmacology*
Bacteria / cytology
Cell Line, Transformed
Cell Wall / chemistry
Cobalt / pharmacology*
Deferoxamine / pharmacology*
Dose-Response Relationship, Drug
Drug Interactions
Gene Expression Regulation / drug effects*
Hypoxia-Inducible Factor 1, alpha Subunit / genetics,  metabolism*
Lipopolysaccharides / pharmacology
Oligodendroglia / drug effects*
Siderophores / pharmacology*
Teichoic Acids / pharmacology
Time Factors
Toll-Like Receptors / genetics,  metabolism
Reg. No./Substance:
0/Antimutagenic Agents; 0/HIF1A protein, human; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/Lipopolysaccharides; 0/Siderophores; 0/Teichoic Acids; 0/Toll-Like Receptors; 56411-57-5/lipoteichoic acid; 70-51-9/Deferoxamine; 7440-48-4/Cobalt; 7646-79-9/cobaltous chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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