| Bacterial community variation in human body habitats across space and time. | |
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MedLine Citation:
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PMID: 19892944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Elucidating the biogeography of bacterial communities on the human body is critical for establishing healthy baselines from which to detect differences associated with diseases. To obtain an integrated view of the spatial and temporal distribution of the human microbiota, we surveyed bacteria from up to 27 sites in seven to nine healthy adults on four occasions. We found that community composition was determined primarily by body habitat. Within habitats, interpersonal variability was high, whereas individuals exhibited minimal temporal variability. Several skin locations harbored more diverse communities than the gut and mouth, and skin locations differed in their community assembly patterns. These results indicate that our microbiota, although personalized, varies systematically across body habitats and time; such trends may ultimately reveal how microbiome changes cause or prevent disease. |
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Authors:
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Elizabeth K Costello; Christian L Lauber; Micah Hamady; Noah Fierer; Jeffrey I Gordon; Rob Knight |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-11-05 |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 326 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-18 Completed Date: 2010-01-21 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 1694-7 Citation Subset: IM |
Affiliation:
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Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bacteria / classification, genetics, isolation & purification* Biodiversity Cluster Analysis DNA, Bacterial / analysis, genetics, isolation & purification DNA, Ribosomal / analysis, genetics, isolation & purification Ear Canal / microbiology* Feces / microbiology* Female Genes, rRNA Hair / microbiology* Humans Male Metagenome* Middle Aged Mouth / microbiology* Nose / microbiology* Phylogeny Principal Component Analysis RNA, Ribosomal, 16S / genetics Skin / microbiology* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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DK64540/DK/NIDDK NIH HHS; DK78669/DK/NIDDK NIH HHS; T32 GM065103-08/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/DNA, Bacterial; 0/DNA, Ribosomal; 0/RNA, Ribosomal, 16S |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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