| Bacteria tune interferon responses by playing with chromatin. | |
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MedLine Citation:
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PMID: 22286704 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Bacterial infections, like their viral counterparts, trigger the onset of innate immune defense mechanisms through the release of cytokines, including interferons (IFNs). While type I and II IFN responses to bacteria have long been explored, type III remains poorly addressed. We have recently reported that the pathogen Listeria monocytogenes triggers the expression of type I and III IFN genes in epithelial cells, and is able to fine-tune downstream signaling at the chromatin level. This bacterium can negatively or positively modulate the expression of interferon-stimulated genes (ISGs) by manipulating the function of BAHD1, a component of a host chromatin-silencing complex. To this end, L. monocytogenes tightly controls the secretion of a BAHD1 inhibitory factor, LntA. Here, we further document the current knowledge about chromatin mechanisms modulating interferon responses during host-bacteria interplay, and discuss their physiological consequences. |
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Authors:
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Alice Lebreton; Pascale Cossart; Hélène Bierne |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-01 |
Journal Detail:
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Title: Virulence Volume: 3 ISSN: 2150-5608 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101531386 Medline TA: Virulence Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Unité des Interactions Bactéries-Cellules; Institut Pasteur; and INSERM U604; and INRA USC2020; Paris, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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