Document Detail


Bacteria in supragingival plaque samples can be killed by low-power laser light in the presence of a photosensitizer.
MedLine Citation:
PMID:  7759386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to determine whether bacteria in supragingival plaque samples could be killed by low-power laser light in the presence of a suitable photosensitizer. Plaque samples were obtained from 10 volunteers, treated with either toluidine blue O (TBO) or aluminum disulphonated phthalocyanine (AlPcS2), and then exposed to light from a helium/neon (HeNe) or gallium aluminium arsenide (GaAs) laser respectively. Following irradiation, substantial reductions were achieved in the total anaerobic count as well as in the number of viable streptococci and actinomyces present in the samples. In the absence of laser light, the sensitizers themselves had little effect on the viability of the bacteria in the plaque samples. The HeNe/TBO combination appeared to be more effective than the GaAs/AlPcS2 combination, achieving log10 reductions of 2.95, 5.40 and 3.34 in the total anaerobic count, streptococci and actinomyces respectively with a light energy dose of 1.31 J. If effective in vivo, lethal photosensitization may be useful as a means of eliminating plaque bacteria from a carious lesion prior to its restoration.
Authors:
M Wilson; T Burns; J Pratten; G J Pearson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of applied bacteriology     Volume:  78     ISSN:  0021-8847     ISO Abbreviation:  J. Appl. Bacteriol.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-06-27     Completed Date:  1995-06-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503050     Medline TA:  J Appl Bacteriol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  569-74     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Eastman Dental Institute for Oral Health Care Sciences, University of London, UK.
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MeSH Terms
Descriptor/Qualifier:
Actinomyces / drug effects,  radiation effects*
Dental Plaque / microbiology*
Gingiva / microbiology
Humans
Indoles / pharmacology
Lasers*
Organometallic Compounds / pharmacology
Photosensitizing Agents / pharmacology
Streptococcus / drug effects,  radiation effects*
Tolonium Chloride / pharmacology
Chemical
Reg. No./Substance:
0/Indoles; 0/Organometallic Compounds; 0/Photosensitizing Agents; 68637-19-4/aluminum phthalocyanine disulfonate; 92-31-9/Tolonium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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