Document Detail


Bacteremia due to Stenotrophomonas maltophilia in patients with hematologic malignancies.
MedLine Citation:
PMID:  11017819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Predisposing factors, clinical characteristics, and antimicrobial treatment of 37 hematology patients with Stenotrophomonas maltophilia bacteremia who were seen at the department of hematology of the University La Sapienza (Rome) from 1987 to 1996 were evaluated. The results were compared with a control group of patients with Pseudomonas aeruginosa bacteremia. Profound neutropenia was more prolonged in the S. maltophilia group (P=.025), severe cellulitis occurred only in S. maltophilia-infected patients (11 [30%]; P=.0002), and the bacteremia presented as breakthrough infection in 56% of the cases due to S. maltophilia (vs. only 24% of those due to P. aeruginosa; P=.002). Acute mortality rates associated with S. maltophilia and P. aeruginosa bacteremia were 24% and 21%, respectively. In both groups, profound neutropenia and hypotension at the onset of bacteremia, duration of profound neutropenia during bacteremia, severity-of-illness score > or =4, and inappropriate antibacterial treatment were factors significantly associated with death. Most S. maltophilia isolates were resistant to aminoglycosides, beta-lactams, and ciprofloxacin. Cotrimoxazole and ticarcillin-clavulanic acid showed borderline activity. Prompt administration of in vitro-active antibiotics may improve the prognosis of S. maltophilia bacteremia, especially for immunocompromised patients, and novel drug combinations are needed for the treatment of severe infections.
Authors:
A Micozzi; M Venditti; M Monaco; A Friedrich; F Taglietti; S Santilli; P Martino
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2000-10-04
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  31     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-11-21     Completed Date:  2000-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  705-11     Citation Subset:  IM    
Affiliation:
Dipartimento di Biotecnologie Cellulari ed Ematologia, Sezione di Ematologia, Università La Sapienza, 00161 Rome, Italy. micozzi@bce.med.uniroma1.it
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Bacteremia / complications,  microbiology*,  mortality
Child
Child, Preschool
Female
Gram-Negative Bacterial Infections / complications,  microbiology*,  mortality
Hematologic Neoplasms / complications*
Hospitals, University / statistics & numerical data
Humans
Male
Middle Aged
Pseudomonas Infections / complications,  microbiology,  mortality
Pseudomonas aeruginosa / isolation & purification
Retrospective Studies
Stenotrophomonas maltophilia / isolation & purification*
Survival Rate
Comments/Corrections
Comment In:
Clin Infect Dis. 2001 Jun 1;32(11):1656   [PMID:  11340542 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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