Document Detail

Baclofen successfully abolished prolonged central hyperthermia in a patient with basilar artery occlusion.
MedLine Citation:
PMID:  19673364     Owner:  NLM     Status:  MEDLINE    
Hyperthermia, not uncommon in severe brainstem stroke, is frequently difficult to control and associated with a poor prognosis and high mortality. Successful treatment of central hyperthermia in patients with brainstem infarction by baclofen has not been described. Following basilar artery occlusion, a 68-year-old female developed prolonged hyperthermia. Her hyperthermia did not respond to any antipyretic treatments. A water-cooling blanket was utilized to control her hyperthermia; however, body temperatures fluctuated at a range of 35.5-40.0 degrees C. After given baclofen 30 mg/day, her body temperatures returned to a normal range and remained stable. Hyperthermia following severe brainstem infarction without any sign of infection or inflammatory sources usually comes from a central origin and is likely associated with dysfunctions of the thermoregulatory system. Baclofen may be one of the treatment choices in patients with neurogenic central hyperthermia.
Yung-Sung Huang; Ming-Chang Hsiao; Meng Lee; Ying-Chih Huang; Jiann-Der Lee
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta neurologica Taiwanica     Volume:  18     ISSN:  1028-768X     ISO Abbreviation:  Acta Neurol Taiwan     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-08-13     Completed Date:  2009-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815355     Medline TA:  Acta Neurol Taiwan     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  118-22     Citation Subset:  IM    
Department of Neurology, Chang Gung Memorial Hospital, Chiayi, Taiwan.
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MeSH Terms
Baclofen / therapeutic use*
Body Temperature Regulation
Brain Stem / blood supply
Fever / drug therapy*,  etiology
Stroke / complications*,  physiopathology
Vertebrobasilar Insufficiency / complications*
Reg. No./Substance:

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